Optimization and Evaluation of the In Vitro Permeation Parameters of Topical Products with Non-Steroidal Anti-Inflammatory Drugs through Strat-M ® Membrane

Pharmaceutical products containing non-steroidal anti-inflammatory drugs (NSAIDs) are among the most prescribed topical formulations used for analgesic and antirheumatic properties. These drugs must overcome the skin barrier to cause a therapeutic effect. Human skin has been widely used as a model t...

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Bibliographic Details
Published in:Pharmaceutics 2021-08, Vol.13 (8), p.1305
Main Authors: Milanowski, Bartłomiej, Wosicka-Frąckowiak, Hanna, Główka, Eliza, Sosnowska, Małgorzata, Woźny, Stanisław, Stachowiak, Filip, Suchenek, Angelika, Wilkowski, Dariusz
Format: Article
Language:English
Subjects:
Aerosols
Anti-inflammatory agents
Design of experiments
diclofenac
etofenamate
ibuprofen
in vitro permeation test
Manufacturers
Manufacturing
Nonsteroidal anti-inflammatory drugs
Optimization
Pharmaceuticals
Plackett–Burman design
Skin
Strat-M® membrane
Variables
Viscosity
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Summary:Pharmaceutical products containing non-steroidal anti-inflammatory drugs (NSAIDs) are among the most prescribed topical formulations used for analgesic and antirheumatic properties. These drugs must overcome the skin barrier to cause a therapeutic effect. Human skin has been widely used as a model to study in vitro drug diffusion and permeation, however, it suffers from many limitations. Therefore, to perform in vitro permeation test (IVPT), we used a Strat-M membrane with diffusion characteristics well-correlated to human skin. This study's objective was to optimize the IVPT conditions using Plackett-Burman experimental design for bio-predictive evaluation of the in vitro permeation rates of five non-steroidal anti-inflammatory drugs (diclofenac, etofenamate, ibuprofen, ketoprofen, naproxen) across Strat-M membrane from commercial topical formulations. The Plackett-Burman factorial design was used to screen the effect of seven factors in eight runs with one additional center point. This tool allowed us to set the sensitive and discriminative IVPT final conditions that can appropriately characterize the NSAIDs formulations. The permeation rate of etofenamate (ETF) across the Strat-M membrane was 1.7-14.8 times faster than other NSAIDs from selected semisolids but 1.6 times slower than the ETF spray formulation.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13081305