Protective Effect of N-Acetyl Cysteine on Chlorpyrifos-Induced Testicular Toxicity in Mice

Chlorpyrifos (CPF), an organophosphate pesticide, is widely used in farms in order to preserve crops and fruits. Previous studies have shown that CPF exposure might cause chronic toxicity in male genital system. The present study investigated the protective effect of N-Acetyl Cysteine (NAC), a poten...

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Bibliographic Details
Published in:International journal of fertility & sterility 2019-04, Vol.13 (1), p.51-56
Main Authors: Kheradmandi, Rasoul, Jorsaraei, Seyed Gholam Ali, Feizi, Farideh, Moghadamnia, Ali Akbar, Neamati, Nahid
Format: Article
Language:English
Subjects:
acetylcysteine
Animals
chlorpyrifos
Morphology
Motility
Original
Pesticides
protective
Sperm
Statistical analysis
Variance analysis
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Summary:Chlorpyrifos (CPF), an organophosphate pesticide, is widely used in farms in order to preserve crops and fruits. Previous studies have shown that CPF exposure might cause chronic toxicity in male genital system. The present study investigated the protective effect of N-Acetyl Cysteine (NAC), a potent antioxidant against testicular toxicity of CPF in male mice. In this experimental study, 42 adult male mice were divided into seven groups, CPF low (0.5 mg/kg.b.w) and high (5 mg/kg.b.w) doses groups, NAC group (35 mg/kg.b.w), NAC+CPF 0/5 mg/kg.b.w, NAC+CPF 5 mg/kg.b.w, dimethyl sulfoxide (DMSO, 0.75% solution mg/kg.b.w) and control group. All treatment were done intraperitoneally. Treatment was conducted for four consecutive weeks (five days each week). However NAC was injected to NAC+CPF groups five days before initiation of the treatment procedure. One week after the last injection, mice were sacrificed using anesthetic gas to evaluate alterations in testicular histology and sperm parameters. Seminiferous tubules area and diameter were significantly diminished in the group treated with 5 mg/kg CPF (P
ISSN:2008-076X
2008-0778
DOI:10.22074/ijfs.2019.5494