Divergent Gemycircularvirus in HIV-Positive Blood, France

We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence inter...

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Bibliographic Details
Published in:Emerging infectious diseases 2015-11, Vol.21 (11), p.2096-2098
Main Authors: Uch, Rathviro, Fournier, Pierre-Edouard, Robert, Catherine, Blanc-Tailleur, Caroline, Galicher, Vital, Barre, Romain, Jordier, François, de Micco, Philippe, Raoult, Didier, Biagini, Philippe
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Algorithms
Allografts
blood
Child
Child, Preschool
Divergent Gemycircularvirus in HIV-Positive Blood, France
DNA, Single-Stranded
Female
France
gemycircularvirus
Graft vs Host Disease
Hematologic Neoplasms
Hematology
Hematopoietic Stem Cell Transplantation
HIV
HIV Infections - epidemiology
HIV Infections - virology
HIV Seropositivity - blood
HIV Seropositivity - virology
HIV-1 - pathogenicity
HLA-DP beta-Chains
Host vs Graft Reaction
Human health and pathology
Humans
Letter
Letters to the Editor
Life Sciences
Male
Microbiology and Parasitology
Middle Aged
Molecular Sequence Data
Unrelated Donors
Virology
viruses
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Summary:We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2111.150486