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Divergent Gemycircularvirus in HIV-Positive Blood, France
We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence inter...
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| Published in: | Emerging infectious diseases 2015-11, Vol.21 (11), p.2096-2098 |
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| creator | Uch, Rathviro Fournier, Pierre-Edouard Robert, Catherine Blanc-Tailleur, Caroline Galicher, Vital Barre, Romain Jordier, François de Micco, Philippe Raoult, Didier Biagini, Philippe |
| description | We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT. |
| doi_str_mv | 10.3201/eid2111.150486 |
| format | article |
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A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.</description><identifier>ISSN: 1080-6040</identifier><identifier>EISSN: 1080-6059</identifier><identifier>DOI: 10.3201/eid2111.150486</identifier><identifier>PMID: 26488181</identifier><language>eng</language><publisher>United States: U.S. National Center for Infectious Diseases</publisher><subject>Adolescent ; Adult ; Aged ; Algorithms ; Allografts ; blood ; Child ; Child, Preschool ; Divergent Gemycircularvirus in HIV-Positive Blood, France ; DNA, Single-Stranded ; Female ; France ; gemycircularvirus ; Graft vs Host Disease ; Hematologic Neoplasms ; Hematology ; Hematopoietic Stem Cell Transplantation ; HIV ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV Seropositivity - blood ; HIV Seropositivity - virology ; HIV-1 - pathogenicity ; HLA-DP beta-Chains ; Host vs Graft Reaction ; Human health and pathology ; Humans ; Letter ; Letters to the Editor ; Life Sciences ; Male ; Microbiology and Parasitology ; Middle Aged ; Molecular Sequence Data ; Unrelated Donors ; Virology ; viruses</subject><ispartof>Emerging infectious diseases, 2015-11, Vol.21 (11), p.2096-2098</ispartof><rights>COPYRIGHT 2015 U.S. National Center for Infectious Diseases</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c694t-fe8f0672378643a2d3f4e9f853e8f9045c62eb3da0420e426cc8b1a5a839100f3</citedby><cites>FETCH-LOGICAL-c694t-fe8f0672378643a2d3f4e9f853e8f9045c62eb3da0420e426cc8b1a5a839100f3</cites><orcidid>0000-0002-2895-5824 ; 0000-0002-0633-5974</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622245/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622245/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26488181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01235994$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Uch, Rathviro</creatorcontrib><creatorcontrib>Fournier, Pierre-Edouard</creatorcontrib><creatorcontrib>Robert, Catherine</creatorcontrib><creatorcontrib>Blanc-Tailleur, Caroline</creatorcontrib><creatorcontrib>Galicher, Vital</creatorcontrib><creatorcontrib>Barre, Romain</creatorcontrib><creatorcontrib>Jordier, François</creatorcontrib><creatorcontrib>de Micco, Philippe</creatorcontrib><creatorcontrib>Raoult, Didier</creatorcontrib><creatorcontrib>Biagini, Philippe</creatorcontrib><title>Divergent Gemycircularvirus in HIV-Positive Blood, France</title><title>Emerging infectious diseases</title><addtitle>Emerg Infect Dis</addtitle><description>We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). 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Fournier, Pierre-Edouard ; Robert, Catherine ; Blanc-Tailleur, Caroline ; Galicher, Vital ; Barre, Romain ; Jordier, François ; de Micco, Philippe ; Raoult, Didier ; Biagini, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c694t-fe8f0672378643a2d3f4e9f853e8f9045c62eb3da0420e426cc8b1a5a839100f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Algorithms</topic><topic>Allografts</topic><topic>blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Divergent Gemycircularvirus in HIV-Positive Blood, France</topic><topic>DNA, Single-Stranded</topic><topic>Female</topic><topic>France</topic><topic>gemycircularvirus</topic><topic>Graft vs Host Disease</topic><topic>Hematologic Neoplasms</topic><topic>Hematology</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>HIV</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - virology</topic><topic>HIV Seropositivity - blood</topic><topic>HIV Seropositivity - virology</topic><topic>HIV-1 - pathogenicity</topic><topic>HLA-DP beta-Chains</topic><topic>Host vs Graft Reaction</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Letter</topic><topic>Letters to the Editor</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Microbiology and Parasitology</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Unrelated Donors</topic><topic>Virology</topic><topic>viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uch, Rathviro</creatorcontrib><creatorcontrib>Fournier, Pierre-Edouard</creatorcontrib><creatorcontrib>Robert, Catherine</creatorcontrib><creatorcontrib>Blanc-Tailleur, Caroline</creatorcontrib><creatorcontrib>Galicher, Vital</creatorcontrib><creatorcontrib>Barre, Romain</creatorcontrib><creatorcontrib>Jordier, François</creatorcontrib><creatorcontrib>de Micco, Philippe</creatorcontrib><creatorcontrib>Raoult, Didier</creatorcontrib><creatorcontrib>Biagini, Philippe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints In Context</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Emerging infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uch, Rathviro</au><au>Fournier, Pierre-Edouard</au><au>Robert, Catherine</au><au>Blanc-Tailleur, Caroline</au><au>Galicher, Vital</au><au>Barre, Romain</au><au>Jordier, François</au><au>de Micco, Philippe</au><au>Raoult, Didier</au><au>Biagini, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Divergent Gemycircularvirus in HIV-Positive Blood, France</atitle><jtitle>Emerging infectious diseases</jtitle><addtitle>Emerg Infect Dis</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>21</volume><issue>11</issue><spage>2096</spage><epage>2098</epage><pages>2096-2098</pages><issn>1080-6040</issn><eissn>1080-6059</eissn><abstract>We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.</abstract><cop>United States</cop><pub>U.S. National Center for Infectious Diseases</pub><pmid>26488181</pmid><doi>10.3201/eid2111.150486</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-2895-5824</orcidid><orcidid>https://orcid.org/0000-0002-0633-5974</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Algorithms Allografts blood Child Child, Preschool Divergent Gemycircularvirus in HIV-Positive Blood, France DNA, Single-Stranded Female France gemycircularvirus Graft vs Host Disease Hematologic Neoplasms Hematology Hematopoietic Stem Cell Transplantation HIV HIV Infections - epidemiology HIV Infections - virology HIV Seropositivity - blood HIV Seropositivity - virology HIV-1 - pathogenicity HLA-DP beta-Chains Host vs Graft Reaction Human health and pathology Humans Letter Letters to the Editor Life Sciences Male Microbiology and Parasitology Middle Aged Molecular Sequence Data Unrelated Donors Virology viruses |
| title | Divergent Gemycircularvirus in HIV-Positive Blood, France |
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