Analysis of clinical cure outcome, macrophages number, cytokines levels and expression of annexin-A1 in the cutaneous infection in patients with Leishmania braziliensis

Leishmania braziliensis, a protozoan prevalent in Brazil, is the known causative agent of cutaneous leishmaniasis (CL). The activation of M1 macrophages is a pivotal factor in the host's ability to eliminate the parasite, whereas M2 macrophages may facilitate parasite proliferation. This study...

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Published in:Revista da Sociedade Brasileira de Medicina Tropical 2024-01, Vol.57, p.e00412
Main Authors: Silva, Joselina Maria da, Silva, Helen Aguiar Lemes da, Sarmento, Ana Lucia Carneiro, Hueb, Marcia, Damazo, Amílcar Sabino
Format: Article
Language:English
Subjects:
Adolescent
Adult
Annexin A1
Cutaneous leishmaniasis
Cytokines
Female
Histopathology
Humans
Leishmania braziliensis
Leishmania braziliensis - immunology
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Cutaneous - pathology
Macrophages - immunology
Major
Male
Middle Aged
Polymerase Chain Reaction
TROPICAL MEDICINE
Young Adult
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Summary:Leishmania braziliensis, a protozoan prevalent in Brazil, is the known causative agent of cutaneous leishmaniasis (CL). The activation of M1 macrophages is a pivotal factor in the host's ability to eliminate the parasite, whereas M2 macrophages may facilitate parasite proliferation. This study analyzed the clinical outcomes of CL and the patients' immunological profiles, focusing on the prevalence of M1 and M2 macrophages, cytokine production, and annexin-A1 (ANXA1) expression in the lesion. Data were obtained by polymerase chain reaction (PCR) and histopathological, immunofluorescence, and cytokine analyses. Patients with exudative and cellular reaction-type (ECR)-type lesions that healed within 90 days showed a significant increase in M1. Conversely, patients with ECR and exudative and granulomatous reaction (EGR)types, who healed within 180 days, showed an elevated number of M2. Cytokines interferon (IFN)-γ and tumor necrosis factor (TNF)-α were higher in ECR lesions that resolved within 90 days (P
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0036-2024