Anti-Staphylococcal Activities of Rosmarinus officinalis and Myrtus communis Essential Oils through ROS-Mediated Oxidative Stress

and essential oils (EOs) are well-known for their ethno-pharmaceutical properties. In the present study, we have analyzed the chemical composition of both EOs by gas chromatography-mass spectrometry. Then we assessed their antibacterial, antibiofilm, and anti-virulence actions against the opportunis...

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Bibliographic Details
Published in:Antibiotics (Basel) 2023-01, Vol.12 (2), p.266
Main Authors: Bowbe, Khadijetou Hamoud, Salah, Karima Bel Hadj, Moumni, Sarra, Ashkan, Mada F, Merghni, Abderrahmen
Format: Article
Language:English
Subjects:
ant-virulence
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Biofilms
Catalase
Chemical composition
Cytotoxicity
essential oil
Essential oils
Gas chromatography
M. communis
Mass spectrometry
Mass spectroscopy
Myrtus communis
Nosocomial infections
Oils & fats
Opportunist infection
Oxidative stress
Pathogens
R. officinalis
Reactive oxygen species
Reagents
RNA polymerase
Rosmarinus officinalis
Staphylococcus aureus
Staphylococcus infections
Virulence
Virulence factors
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Summary:and essential oils (EOs) are well-known for their ethno-pharmaceutical properties. In the present study, we have analyzed the chemical composition of both EOs by gas chromatography-mass spectrometry. Then we assessed their antibacterial, antibiofilm, and anti-virulence actions against the opportunistic pathogen . The cytotoxic effect of agents tested against this bacterium was investigated by monitoring reactive oxygen-species (ROS) generation and antioxidant-enzyme (catalase) production. Regarding the antistaphylococcal effects, our results showed antibacterial efficacy of both Eos and their combination, where the minimum inhibitory concentrations ranged between 0.7 and 11.25 mg/mL. A combination of tested agents showed the highest anti-hemolytic and anti-protease effects. Additionally, association between EOs displayed more potency against the development of biofilm performed by with percentage of removal reaching 74%. The inhibitory impacts of EOs on virulence factors were discovered to be concentration-dependent. Furthermore, our results provide insight on the abilities of and EOs, as well as their potential in combination, to generate ROS and affect oxidative stress enzyme catalase in , leading to their antagonistic effect against this pathogen.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12020266