Molecular mechanism study of HGF/c-MET pathway activation and immune regulation for a tumor diagnosis model

• Published in: Cancer cell international 2021-07, Vol.21 (1), p.374-374, Article 374
• Main Authors: Shen, Zhibo, Xue, Wenhua, Zheng, Yuanyuan, Geng, Qishun, Wang, Le, Fan, Zhirui, Wang, Wenbin, Yue, Ying, Zhai, Yunkai, Li, Lifeng, Zhao, Jie
• Format: Article
• Language: English
• Subjects: Antagonists; Batch processing; c-MET; c-Met protein; Cancer; Clinical trials; Diagnosis; Gene expression; Growth factors; Hepatocyte growth factor; HGF; Immune cells; Immune infiltration; Immunoregulation; Infiltration; Kinases; Lymphocytes; Medical prognosis; Mesenchyme; Metastases; Pathway score; Primary Research; Prognosis; RNAseq; Signal transduction; Solid tumors; Statistical analysis; Transcriptomes; Tumor microenvironment; Tumors
• ISSN: 1475-2867; 1475-2867
• DOI: 10.1186/s12935-021-02051-2

Hepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Given the role of this signaling pathway, the primary therapeutic direction focuses on identifying and designing HGF inhibitors, antagonists and other molecules to block the binding of HGF to C-MET, thereby limiting the abnormal state of other downstream genes. This study focuses on the analysis of immune-related genes and corresponding immune functions that are significantly associated with the HGF/c-MET pathway using transcriptome data from 11 solid tumors. We systematically analyzed 11 different cancers, including expression correlation, immune infiltration, tumor diagnosis and survival prognosis from HGF/c-MET pathway and immune regulation, two biological mechanisms having received extensive attention in cancer analysis. We found that the HGF/c-MET pathway affected the tumor microenvironment mainly by interfering with expression levels of other genes. Immune infiltration is another critical factor involved in changes to the tumor microenvironment. The downstream immune-related genes activated by the HGF/c-MET pathway regulate immune-related pathways, which in turn affect the degree of infiltration of immune cells. Immune infiltration is significantly associated with cancer development and prognosis.