Age-Induced Differential Changes in the Central and Colonic Human Circadian Oscillators

Aging modifies not only multiple cellular and homeostatic systems, but also biological rhythms. The circadian system is driven by a central hypothalamic oscillator which entrains peripheral oscillators, in both cases underlain by circadian genes. Our aim was to characterize the effect of aging in th...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-01, Vol.21 (2), p.674
Main Authors: Camello-Almaraz, Cristina, Martin-Cano, Francisco E, Santos, Francisco J, Espin, Mª Teresa, Antonio Madrid, Juan, Pozo, Maria J, Camello, Pedro J
Format: Article
Language:English
Subjects:
Age
Aging
Aging (artificial)
BMAL1 protein
Calcium ions
Calcium signalling
calcium signals
Circadian rhythm
Circadian rhythms
clock genes
Colon
contractility
Explants
Gene expression
Genes
Hypothalamus
Molecular oscillators
Motor activity
Muscle contraction
Muscles
Oscillators
Pacemakers
Period 1 protein
Physiology
Smooth muscle
Variables
Wrist
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Summary:Aging modifies not only multiple cellular and homeostatic systems, but also biological rhythms. The circadian system is driven by a central hypothalamic oscillator which entrains peripheral oscillators, in both cases underlain by circadian genes. Our aim was to characterize the effect of aging in the circadian expression of clock genes in the human colon. Ambulatory recordings of the circadian rhythms of skin wrist temperature, motor activity and the integrated variable TAP (temperature, activity and position) were dampened by aging, especially beyond 74 years of age. On the contrary, quantitative analysis of genes expression in the muscle layer of colonic explants during 24 h revealed that the circadian expression of , and genes, was larger beyond that age. In vitro experiments showed that aging induced a parallel increase in the myogenic contractility of the circular colonic muscle. This effect was not accompanied by enhancement of Ca signals. In conclusion, we describe here for the first time the presence of a molecular oscillator in the human colon. Aging has a differential effect on the systemic circadian rhythms, that are impaired by aging, and the colonic oscillator, that is strengthened in parallel with the myogenic contractility.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21020674