The multifaceted interactions between Newcastle disease virus proteins and host proteins: a systematic review

Newcastle disease virus (NDV) typically induces severe illness in poultry and results in significant economic losses for the worldwide poultry sector. NDV, an RNA virus with a single-stranded negative-sense genome, is susceptible to mutation and immune evasion during viral transmission, thus imposin...

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Bibliographic Details
Published in:Virulence 2024-12, Vol.15 (1), p.2299182-2299182
Main Authors: Lu, Xiaolong, Wang, Xiaoquan, Liu, Xiufan, Liu, Xiaowen
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents
host immune responses
Host Microbial Interactions
host proteins
Immune Evasion
Newcastle disease virus
Newcastle disease virus - metabolism
pathogenesis
protein interaction
Review
viral proteins
Virus Diseases - metabolism
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Summary:Newcastle disease virus (NDV) typically induces severe illness in poultry and results in significant economic losses for the worldwide poultry sector. NDV, an RNA virus with a single-stranded negative-sense genome, is susceptible to mutation and immune evasion during viral transmission, thus imposing enormous challenges to avian health and poultry production. NDV is composed of six structural proteins and two nonstructural proteins that exert pivotal roles in viral infection and antiviral responses by interacting with host proteins. Nowadays, there is a particular focus on the mechanisms of virus-host protein interactions in NDV research, yet a comprehensive overview of such research is still lacking. Herein, we briefly summarize the mechanisms regarding the effects of virus-host protein interaction on viral infection, pathogenesis, and host immune responses. This review can not only enhance the present comprehension of the mechanism underlying NDV and host interplay, but also furnish a point of reference for the advancement of antiviral measures.
ISSN:2150-5594
2150-5608
DOI:10.1080/21505594.2023.2299182