The role of TIGAR in nervous system diseases

TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions incl...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in aging neuroscience 2022-11, Vol.14, p.1023161-1023161
Main Authors: Huang, Bei, Lang, Xiaoling, Li, Xihong
Format: Article
Language:English
Subjects:
Aging Neuroscience
brain tumors
seizures
stroke
TIGAR
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c396t-aabc0d3998add2f5dc0633ad7c00cff15125f522e1b45e00bc82bf06e3a468913
container_end_page 1023161
container_issue
container_start_page 1023161
container_title Frontiers in aging neuroscience
container_volume 14
creator Huang, Bei
Lang, Xiaoling
Li, Xihong
description TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions include anti-oxidative stress, reducing inflammation, maintaining mitochondrial function, inhibiting apoptosis, reducing autophagy etc. This paper reviews the research of TIGAR in neurological diseases, including stroke, Parkinson’s disease (PD), Alzheimer’s disease (AD), seizures and brain tumors, aiming to provide reference for the development of new therapeutic targets.
doi_str_mv 10.3389/fnagi.2022.1023161
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_284b00fa309f439c8e988f6aeacc0340</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_284b00fa309f439c8e988f6aeacc0340</doaj_id><sourcerecordid>2740906874</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-aabc0d3998add2f5dc0633ad7c00cff15125f522e1b45e00bc82bf06e3a468913</originalsourceid><addsrcrecordid>eNpVkU1LA0EMhhdRULR_wNMePdiamexOZy5CKX4UBEHqecjOZtot2x2d2Qr-e2tbxOaSkLw8CXmz7FrACFGbO9_RohlJkHIkQKJQ4iS7EErhsEBVnv6rz7NBSivYBiJAqS-y2_mS8xhazoPP57OnyVvedHnH8StsUp6-U8_rvG4SU-J0lZ15ahMPDvkye398mE-fhy-vT7Pp5GXo0Kh-SFQ5qNEYTXUtfVk7UIhUjx2A816UQpa-lJJFVZQMUDktKw-KkQqljcDLbLbn1oFW9iM2a4rfNlBjd40QF5Zi37iWrdRFBeAJwfgCjdNstPaKmJwDLGDLut-zPjbVmmvHXR-pPYIeT7pmaRfhyxqlpdwdc3MAxPC54dTbdZMcty11vP2RleMCDCg9LrZSuZe6GFKK7P_WCLC_VtmdVfbXKnuwCn8Ad2iHXg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2740906874</pqid></control><display><type>article</type><title>The role of TIGAR in nervous system diseases</title><source>Open Access: PubMed Central</source><creator>Huang, Bei ; Lang, Xiaoling ; Li, Xihong</creator><creatorcontrib>Huang, Bei ; Lang, Xiaoling ; Li, Xihong</creatorcontrib><description>TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions include anti-oxidative stress, reducing inflammation, maintaining mitochondrial function, inhibiting apoptosis, reducing autophagy etc. This paper reviews the research of TIGAR in neurological diseases, including stroke, Parkinson’s disease (PD), Alzheimer’s disease (AD), seizures and brain tumors, aiming to provide reference for the development of new therapeutic targets.</description><identifier>ISSN: 1663-4365</identifier><identifier>EISSN: 1663-4365</identifier><identifier>DOI: 10.3389/fnagi.2022.1023161</identifier><language>eng</language><publisher>Frontiers Media S.A</publisher><subject>Aging Neuroscience ; brain tumors ; seizures ; stroke ; TIGAR</subject><ispartof>Frontiers in aging neuroscience, 2022-11, Vol.14, p.1023161-1023161</ispartof><rights>Copyright © 2022 Huang, Lang and Li. 2022 Huang, Lang and Li</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c396t-aabc0d3998add2f5dc0633ad7c00cff15125f522e1b45e00bc82bf06e3a468913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682291/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682291/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Huang, Bei</creatorcontrib><creatorcontrib>Lang, Xiaoling</creatorcontrib><creatorcontrib>Li, Xihong</creatorcontrib><title>The role of TIGAR in nervous system diseases</title><title>Frontiers in aging neuroscience</title><description>TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions include anti-oxidative stress, reducing inflammation, maintaining mitochondrial function, inhibiting apoptosis, reducing autophagy etc. This paper reviews the research of TIGAR in neurological diseases, including stroke, Parkinson’s disease (PD), Alzheimer’s disease (AD), seizures and brain tumors, aiming to provide reference for the development of new therapeutic targets.</description><subject>Aging Neuroscience</subject><subject>brain tumors</subject><subject>seizures</subject><subject>stroke</subject><subject>TIGAR</subject><issn>1663-4365</issn><issn>1663-4365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkU1LA0EMhhdRULR_wNMePdiamexOZy5CKX4UBEHqecjOZtot2x2d2Qr-e2tbxOaSkLw8CXmz7FrACFGbO9_RohlJkHIkQKJQ4iS7EErhsEBVnv6rz7NBSivYBiJAqS-y2_mS8xhazoPP57OnyVvedHnH8StsUp6-U8_rvG4SU-J0lZ15ahMPDvkye398mE-fhy-vT7Pp5GXo0Kh-SFQ5qNEYTXUtfVk7UIhUjx2A816UQpa-lJJFVZQMUDktKw-KkQqljcDLbLbn1oFW9iM2a4rfNlBjd40QF5Zi37iWrdRFBeAJwfgCjdNstPaKmJwDLGDLut-zPjbVmmvHXR-pPYIeT7pmaRfhyxqlpdwdc3MAxPC54dTbdZMcty11vP2RleMCDCg9LrZSuZe6GFKK7P_WCLC_VtmdVfbXKnuwCn8Ad2iHXg</recordid><startdate>20221109</startdate><enddate>20221109</enddate><creator>Huang, Bei</creator><creator>Lang, Xiaoling</creator><creator>Li, Xihong</creator><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20221109</creationdate><title>The role of TIGAR in nervous system diseases</title><author>Huang, Bei ; Lang, Xiaoling ; Li, Xihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-aabc0d3998add2f5dc0633ad7c00cff15125f522e1b45e00bc82bf06e3a468913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aging Neuroscience</topic><topic>brain tumors</topic><topic>seizures</topic><topic>stroke</topic><topic>TIGAR</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Bei</creatorcontrib><creatorcontrib>Lang, Xiaoling</creatorcontrib><creatorcontrib>Li, Xihong</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in aging neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Bei</au><au>Lang, Xiaoling</au><au>Li, Xihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of TIGAR in nervous system diseases</atitle><jtitle>Frontiers in aging neuroscience</jtitle><date>2022-11-09</date><risdate>2022</risdate><volume>14</volume><spage>1023161</spage><epage>1023161</epage><pages>1023161-1023161</pages><issn>1663-4365</issn><eissn>1663-4365</eissn><abstract>TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions include anti-oxidative stress, reducing inflammation, maintaining mitochondrial function, inhibiting apoptosis, reducing autophagy etc. This paper reviews the research of TIGAR in neurological diseases, including stroke, Parkinson’s disease (PD), Alzheimer’s disease (AD), seizures and brain tumors, aiming to provide reference for the development of new therapeutic targets.</abstract><pub>Frontiers Media S.A</pub><doi>10.3389/fnagi.2022.1023161</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1663-4365
ispartof Frontiers in aging neuroscience, 2022-11, Vol.14, p.1023161-1023161
issn 1663-4365
1663-4365
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_284b00fa309f439c8e988f6aeacc0340
source Open Access: PubMed Central
subjects Aging Neuroscience
brain tumors
seizures
stroke
TIGAR
title The role of TIGAR in nervous system diseases
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T23%3A37%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20TIGAR%20in%20nervous%20system%20diseases&rft.jtitle=Frontiers%20in%20aging%20neuroscience&rft.au=Huang,%20Bei&rft.date=2022-11-09&rft.volume=14&rft.spage=1023161&rft.epage=1023161&rft.pages=1023161-1023161&rft.issn=1663-4365&rft.eissn=1663-4365&rft_id=info:doi/10.3389/fnagi.2022.1023161&rft_dat=%3Cproquest_doaj_%3E2740906874%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c396t-aabc0d3998add2f5dc0633ad7c00cff15125f522e1b45e00bc82bf06e3a468913%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2740906874&rft_id=info:pmid/&rfr_iscdi=true