Ferroptosis in COVID-19-related liver injury: A potential mechanism and therapeutic target

The outbreak and worldwide spread of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a threat to global public health. SARS-CoV-2 infection not only impacts the respiratory system but also causes hepatic injury. Ferroptos...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2022-07, Vol.12, p.922511-922511
Main Authors: Chen, Yunqing, Xu, Yan, Zhang, Kan, Shen, Liang, Deng, Min
Format: Article
Language:English
Subjects:
Cellular and Infection Microbiology
COVID-19
ferroptosis
hyperferritinemia
liver
SARS-CoV-2
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Summary:The outbreak and worldwide spread of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a threat to global public health. SARS-CoV-2 infection not only impacts the respiratory system but also causes hepatic injury. Ferroptosis, a distinct iron-dependent form of non-apoptotic cell death, has been investigated in various pathological conditions, such as cancer, ischemia/reperfusion injury, and liver diseases. However, whether ferroptosis takes part in the pathophysiological process of COVID-19-related liver injury has not been evaluated yet. This review highlights the pathological changes in COVID-19-related liver injury and presents ferroptosis as a potential mechanism in the pathological process. Ferroptosis, as a therapeutic target for COVID-19-related liver injury, is also discussed. Discoveries in these areas will improve our understanding of strategies to prevent and treat hepatic injuries caused by COVID-19.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.922511