Towards Understanding the Genetic Nature of Vasovagal Syncope

Syncope, defined as a transient loss of consciousness caused by transient global cerebral hypoperfusion, affects 30–40% of humans during their lifetime. Vasovagal syncope (VVS) is the most common cause of syncope, the etiology of which is still unclear. This review summarizes data on the genetics of...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2021-10, Vol.22 (19), p.10316
Main Authors: Matveeva, Natalia, Titov, Boris, Bazyleva, Elizabeth, Pevzner, Alexander, Favorova, Olga
Format: Article
Language:English
Subjects:
complex disorders
Consciousness
Etiology
Fainting
Families & family life
Family medical history
Females
Genetic disorders
Genetic factors
genetics
Genomes
Health risk assessment
Hypotension
Injuries
Males
Parents & parenting
Pathogenesis
Patients
Polygenic inheritance
Review
susceptibility
Syncope
Twin studies
Twins
Vasovagal syncope
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Syncope, defined as a transient loss of consciousness caused by transient global cerebral hypoperfusion, affects 30–40% of humans during their lifetime. Vasovagal syncope (VVS) is the most common cause of syncope, the etiology of which is still unclear. This review summarizes data on the genetics of VVS, describing the inheritance pattern of the disorder, candidate gene association studies and genome-wide studies. According to this evidence, VVS is a complex disorder, which can be caused by the interplay between genetic factors, whose contribution varies from monogenic Mendelian inheritance to polygenic inherited predisposition, and external factors affecting the monogenic (resulting in incomplete penetrance) and polygenic syncope types.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms221910316