Postoperative non‐steroidal anti‐inflammatory drugs and anastomotic leakage after gastrointestinal anastomoses: Systematic review and meta‐analysis

Aim Non‐steroidal anti‐inflammatory drugs (NSAIDs) are commonly used to control postoperative pain; however, their postoperative use has been associated with anastomotic leakage after gastrointestinal surgery. This systematic review and meta‐analysis aimed to determine the correlation between the us...

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Bibliographic Details
Published in:Annals of gastroenterological surgery 2020-01, Vol.4 (1), p.64-75
Main Authors: Jamjittrong, Supaschin, Matsuda, Akihisa, Matsumoto, Satoshi, Kamonvarapitak, Tunyaporn, Sakurazawa, Nobuyuki, Kawano, Youichi, Yamada, Takeshi, Suzuki, Hideyuki, Miyashita, Masao, Yoshida, Hiroshi
Format: Article
Language:English
Subjects:
anastomotic leakage
Cancer
Cell adhesion & migration
cyclooxygenase inhibitor
gastrointestinal surgery
Hospital costs
Meta-analysis
Nonsteroidal anti-inflammatory drugs
non‐steroidal anti‐inflammatory drugs
Pain
Postoperative period
Quality
Software
Studies
Surgery
Systematic Review
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Summary:Aim Non‐steroidal anti‐inflammatory drugs (NSAIDs) are commonly used to control postoperative pain; however, their postoperative use has been associated with anastomotic leakage after gastrointestinal surgery. This systematic review and meta‐analysis aimed to determine the correlation between the use of NSAIDs and anastomotic leakage. Methods We conducted a comprehensive electronic literature search up to August 2018 to identify studies comparing anastomotic leakage in patients with and without postoperative NSAID use following gastrointestinal surgery. We then carried out a meta‐analysis using random‐effects models to calculate odds ratios (OR) with 95% confidence intervals (CI). Results Twenty‐four studies were included in this meta‐analysis, including a total of 31 877 patients. Meta‐analysis showed a significant association between NSAID use and anastomotic leakage (OR 1.73; 95% CI = 1.31‐2.29, P 
ISSN:2475-0328
2475-0328
DOI:10.1002/ags3.12300