Chronic Chagas Cardiomyopathy Patients and Resynchronization Therapy: a Survival Analysis

• Published in: Revista brasileira de cirurgia cardiovascular 2018-01, Vol.33 (1), p.82-88
• Main Authors: Menezes Junior, Antônio da Silva, Lopes, Cynthia Caetano, Cavalcante, Patrícia Freire, Martins, Edésio
• Format: Article
• Language: English
• Subjects: CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy - methods; Chagas Cardiomyopathy - mortality; Chagas Cardiomyopathy - therapy; Chagas Disease; Chronic Disease; Cross-Sectional Studies; Female; Heart Failure; Humans; Male; Middle Aged; Original; Retrospective Studies; SURGERY; Survival Analysis
• ISSN: 1678-9741; 0102-7638; 1678-9741
• DOI: 10.21470/1678-9741-2017-0134

Chagas disease represents an important health problem with socioeconomic impacts in many Latin-American countries. It is estimated that 20% to 30% of the people infected by Trypanosoma cruzi will develop chronic Chagas cardiomyopathy (CCC), which is generally accompanied by heart failure (HF). Cardiac resynchronization therapy (CRT) may be indicated for patients with HF and electromechanical dysfunctions. The primary endpoint of this study was to analyze the response to CRT in patients with CCC, while the secondary endpoint was to estimate the survival rates of CRT responder patients. This is an observational, cross-sectional and retrospective study. The records of 50 patients with CRT pacing devices implanted between June 2009 and March 2017 were analyzed. For statistical analyses, Pearson's correlation was used along with Student's t-test, and survival was analyzed using the Kaplan-Meier method. A P value of