Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

Funded within the European Metrology Research Programme (EMRP) [1], the joint research project "Biologically weighted quantities in radiotherapy" (BioQuaRT) [2] aims to develop measurement and simulation techniques for determining the physical properties of ionising particle tracks on diff...

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Bibliographic Details
Published in:EPJ Web of conferences 2014-01, Vol.77, p.00021-1-00021-7
Main Authors: Rabus, Hans, Palmans, Hugo, Hilgers, Gerhard, Sharpe, Peter, Pinto, Massimo, Villagrasa, Carmen, Nettelbeck, Heidi, Moro, Davide, Pola, Andrea, Pszona, Stanislaw, Teles, Pedro
Format: Article
Language:English
Subjects:
Biological effects
Deoxyribonucleic acid
Ion beams
Nanostructure
Packages
Particle tracks
Radiation damage
Radiotherapy
Research projects
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Summary:Funded within the European Metrology Research Programme (EMRP) [1], the joint research project "Biologically weighted quantities in radiotherapy" (BioQuaRT) [2] aims to develop measurement and simulation techniques for determining the physical properties of ionising particle tracks on different length scales (about 2 nm to 10 mu m), and to investigate the correlation of these track structure characteristics with the biological effects of radiation at the cellular level. Work package 1 develops micro-calorimeter prototypes for the direct measurement of lineal energy and will characterise their response for different ion beams by experiment and modelling. Work package 2 develops techniques to measure particle track structure on different length scales in the nanometre range as well as a measurement device integrating a silicon microdosimeter and a nanodosimeter. Work package 3 investigates the indirect effects of radiation based on probes for quantifying particular radical and reactive oxygen species (ROS). Work package 4 focuses on the biological aspects of radiation damage and will produce data on initial DNA damage and late effects for radiotherapy beams of different qualities. Work package 5 provides evaluated data sets of DNA cross-sections and develops a multi-scale model to address microscopic and nanometric track structure properties. The project consortium includes three linked researchers holding so-called Researcher Excellence Grants, who carry out ancillary investigations such as developing and benchmarking a new biophysical model for induction of early radiation damage and developing methods for the translation of quantities derived from particle track structure to clinical applications in ion beam therapy.
ISSN:2100-014X
2100-014X
DOI:10.1051/epjconf/20147700021