Multiple Sclerosis-A Demyelinating Disorder and Its Dental Considerations-A Literature Review with Own Case Report

• Published in: Brain sciences 2023-06, Vol.13 (7), p.1009
• Main Authors: Al Johani, Khalid, Fudah, Mashael, Al-Zahrani, Mohammad, Abed, Hassan, Srivastava, Kumar Chandan, Shrivastava, Deepti, Cicciù, Marco, Minervini, Giuseppe
• Format: Article
• Language: English
• Subjects: Antigens; Autoimmune diseases; B cells; biological products; Case reports; Central nervous system; Corticosteroids; Cytokines; demyelinating diseases; Demyelination; Development and progression; Drug interaction; Dysphagia; Epstein-Barr virus; Etiology; Females; Health aspects; Immunosuppressive agents; Inflammation; Literature reviews; Medicine, Preventive; Multiple sclerosis; Mutation; Myelin; Nervous system; Neuralgia; oral manifestations; oral medicine; Paralysis; Paresthesia; Pathogenesis; Patients; Pediatrics; Periodontal diseases; Preventive health services; Review; Spinal cord; trigeminal neuralgia; Tumor necrosis factor-TNF; Vitamin D
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci13071009

Multiple sclerosis (MS) is a chronic, autoimmune condition that primarily affects the myelin sheath covering the neurons of the central nervous system, including those of the brain and spinal cord. Although the etiology is not completely understood, various factors, such as genetic infections and environmental background, play a role in the pathogenesis. Repeated active episodes of MS characterized with marked inflammation results in the scarring of particular nerve segments, and eventually results in functional impairment over a period of time. Based on the clinical course of the disease, four clinical types of MS have been identified, with the relapsing-remitting type being the commonest. MS is known to occur more commonly in females in the age group of 20-40 years. Dysarthria, fatigue, muscle spasm, and numbness are the common presenting symptoms of MS. Diagnosis is generally achieved with MRI brain scans, showing demyelination plaques and lumbar puncture. Treatment of MS's acute phase includes high doses of corticosteroids; whereas preventive treatment of MS includes the prescription of immunosuppressive therapy, including biologics. A large group of MS patients present with oral manifestations, including dysphagia, dysarthria, temporomandibular joint (TMJ) disturbances, facial palsy, and chronic periodontal diseases. Other typical oral manifestations seen in MS patients include trigeminal neuralgia, paresthesia, or orofacial pain. Dental treatment and following drug prescription needs to be tailored to each patient, as there is a possibility of drug interactions. This paper presents a comprehensive, updated review of MS, with emphasis on oral manifestations and dental considerations. Additionally, it presents a case of a 40-year-old female diagnosed with MS that was presented to a dental hospital. The report discusses the oral manifestations and dental management.