Translating Precision Health for Pediatrics: A Scoping Review

Precision health aims to personalize treatment and prevention strategies based on individual genetic differences. While it has significantly improved healthcare for specific patient groups, broader translation faces challenges with evidence development, evidence appraisal, and implementation. These...

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Bibliographic Details
Published in:Children (Basel) 2023-05, Vol.10 (5), p.897
Main Authors: Subasri, Mathushan, Cressman, Celine, Arje, Danielle, Schreyer, Leighton, Cooper, Erin, Patel, Komal, Ungar, Wendy J, Barwick, Melanie, Denburg, Avram, Hayeems, Robin Z
Format: Article
Language:English
Subjects:
Biomarkers
Children
Childrens health
Clinical medicine
Cystic fibrosis
Data collection
Dimensional analysis
evidence development
Health aspects
Health care reform
health technology assessment
implementation
Mutation
Patients
Pediatrics
precision health
Precision medicine
priority-setting
Review
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Summary:Precision health aims to personalize treatment and prevention strategies based on individual genetic differences. While it has significantly improved healthcare for specific patient groups, broader translation faces challenges with evidence development, evidence appraisal, and implementation. These challenges are compounded in child health as existing methods fail to incorporate the physiology and socio-biology unique to childhood. This scoping review synthesizes the existing literature on evidence development, appraisal, prioritization, and implementation of precision child health. PubMed, Scopus, Web of Science, and Embase were searched. The included articles were related to pediatrics, precision health, and the translational pathway. Articles were excluded if they were too narrow in scope. In total, 74 articles identified challenges and solutions for putting pediatric precision health interventions into practice. The literature reinforced the unique attributes of children and their implications for study design and identified major themes for the value assessment of precision health interventions for children, including clinical benefit, cost-effectiveness, stakeholder values and preferences, and ethics and equity. Tackling these identified challenges will require developing international data networks and guidelines, re-thinking methods for value assessment, and broadening stakeholder support for the effective implementation of precision health within healthcare organizations. This research was funded by the SickKids Precision Child Health Catalyst Grant.
ISSN:2227-9067
2227-9067
DOI:10.3390/children10050897