Management of Candida glabrata infectious crystalline keratopathy with endophthalmitis following penetrating keratoplasty

A 33-year-old male underwent an optical keratoplasty elsewhere in the right eye following which he developed endophthalmitis and subsequently underwent a pars plana vitrectomy and lensectomy. At presentation, he had a deep stromal crystalline infiltration along the graft-host junction. A large thera...

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Bibliographic Details
Published in:Indian journal of ophthalmology 2018-07, Vol.66 (7), p.1012-1014
Main Authors: Nagpal, Ritu, Chaurasia, Sunita, Joseph, Joveeta, Tyagi, Mudit, Rani, Padmaja, Ramappa, Muralidhar, Shah, Rikin
Format: Article
Language:English
Subjects:
Bacterial infections
Candida
Candida albicans
Candida glabrata
Candidiasis
Care and treatment
Case Reports
Case studies
Complications and side effects
Consent
Cornea
Corneal transplantation
Development and progression
Endophthalmitis
Epidemiology
Infections
infectious crystalline keratopathy
Ophthalmology
Pathogenesis
Patients
penetrating keratoplasty
Yeast
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Summary:A 33-year-old male underwent an optical keratoplasty elsewhere in the right eye following which he developed endophthalmitis and subsequently underwent a pars plana vitrectomy and lensectomy. At presentation, he had a deep stromal crystalline infiltration along the graft-host junction. A large therapeutic keratoplasty was performed, and the excised corneal button was evaluated. Histopathology revealed gram-positive round-to-oval budding structures and microbiology identified the organism as Candida glabrata. He was treated with antifungals in the postoperative period. At 4 months after therapeutic keratoplasty, the patient developed recurrent endophthalmitis, following stoppage of antifungals. The treatment was reinstituted for another year, and the patient did well with a clear graft at 18-month-follow-up period after the recurrence episode. Management of infectious crystalline keratopathy with endophthalmitis is a challenging situation and requires long-term treatment.
ISSN:0301-4738
1998-3689
DOI:10.4103/ijo.IJO_1106_17