Diagnostic and prognostic implications of 2018 guideline for the diagnosis of idiopathic pulmonary fibrosis in clinical practice

The purpose of this study was to evaluate the implications of the 2018 updated guideline for the diagnosis of idiopathic pulmonary fibrosis (IPF) in clinical practice compared to 2011 guideline. This study involved 535 patients including 339 IPF and 196 non-IPF, and we retrospectively evaluated CT c...

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Bibliographic Details
Published in:Scientific reports 2021-08, Vol.11 (1), p.16481-16481, Article 16481
Main Authors: Choe, Jooae, Kwon, Byoung Soo, Do, Kyung-Hyun, Hwang, Hee Sang, Song, Jin Woo, Chae, Eun Jin
Format: Article
Language:English
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692/699/1785
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Clinical medicine
Diagnosis
Fibrosis
Humanities and Social Sciences
Lung diseases
Lymphocytes
multidisciplinary
Patients
Pulmonary fibrosis
Science
Science (multidisciplinary)
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Summary:The purpose of this study was to evaluate the implications of the 2018 updated guideline for the diagnosis of idiopathic pulmonary fibrosis (IPF) in clinical practice compared to 2011 guideline. This study involved 535 patients including 339 IPF and 196 non-IPF, and we retrospectively evaluated CT classifications of usual interstitial pneumonia (UIP) by two guidelines. Interobserver agreement of 2018 criteria showed moderate reliability (κ = 0.53) comparable to 2011 (κ = 0.56) but interobserver agreement for probable UIP was fair (κ = 0.40). CT pattern of indeterminate for UIP was associated with better prognosis compared with the other groups (adjusted hazard ratio [HR] = 0.36, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-95728-7