The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis

Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs). However, how BMSC differentiation affects hematopoiesis is poorly...

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Bibliographic Details
Published in:Stem cells international 2018-01, Vol.2018 (2018), p.1-13
Main Authors: Li, Zhongjun, Zhong, Jiang F., Xiang, Yang, Ran, Qian, Zhang, Weiwei, Wu, Jiang, Li, Shengwen Calvin
Format: Article
Language:English
Subjects:
Adipocytes
Aging
B cells
Bias
Bone marrow
Bone marrow transplantation
Cancer
Cell cycle
Chemotherapy
Differentiation
Gene expression
Hematopoiesis
Hematopoietic stem cells
Irradiation
Mesenchymal stem cells
Mesenchyme
Progeny
Radiation
Recovery
Review
Rodents
Stem cells
Stromal cells
Transplantation
Transplants & implants
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Summary:Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs). However, how BMSC differentiation affects hematopoiesis is poorly understood. In this review, we focus on the role of BMSC differentiation in hematopoiesis. We discussed the role of BMSCs and their progeny in hematopoiesis. We also examine the mechanisms that cause differentiation bias of BMSCs in stress conditions including aging, irradiation, and chemotherapy. Moreover, the differentiation balance of BMSCs is crucial to hematopoiesis. We highlight the negative effects of differentiation bias of BMSCs on hematopoietic recovery after bone marrow transplantation. Keeping the differentiation balance of BMSCs is critical for hematopoietic recovery. This review summarises current understanding about how BMSC differentiation affects hematopoiesis and its potential application in improving hematopoietic recovery after bone marrow transplantation.
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2018/1540148