The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs—Therapeutic potential exploration in lung injury

Since 2005, GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) have been developed as therapeutic agents for type 2 diabetes (T2D). GLP-1R is not only expressed in pancreatic islets but also other organs, especially the lung. However, controversy on extra-pancreatic GLP-1R expression still needs to be furt...

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Bibliographic Details
Published in:Acta pharmaceutica Sinica. B 2022-11, Vol.12 (11), p.4040-4055
Main Authors: Pang, Juan, Feng, Jia Nuo, Ling, Wenhua, Jin, Tianru
Format: Article
Language:English
Subjects:
Anti-inflammation
Exenatide
GLP-1R
GLP-1RAs
Liraglutide
Lung injury
MSC-based therapy
Review
TxNIP
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Summary:Since 2005, GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) have been developed as therapeutic agents for type 2 diabetes (T2D). GLP-1R is not only expressed in pancreatic islets but also other organs, especially the lung. However, controversy on extra-pancreatic GLP-1R expression still needs to be further resolved, utilizing different tools including the use of more reliable GLP-1R antibodies in immune-staining and co-immune-staining. Extra-pancreatic expression of GLP-1R has triggered extensive investigations on extra-pancreatic functions of GLP-1RAs, aiming to repurpose them into therapeutic agents for other disorders. Extensive studies have demonstrated promising anti-inflammatory features of GLP-1RAs. Whether those features are directly mediated by GLP-1R expressed in immune cells also remains controversial. Following a brief review on GLP-1 as an incretin hormone and the development of GLP-1RAs as therapeutic agents for T2D, we have summarized our current understanding of the anti-inflammatory features of GLP-1RAs and commented on the controversy on extra-pancreatic GLP-1R expression. The main part of this review is a literature discussion on GLP-1RA utilization in animal models with chronic airway diseases and acute lung injuries, including studies on the combined use of mesenchymal stem cell (MSC) based therapy. This is followed by a brief summary. T2D drugs known as GLP-1RAs can target GLP-1R which is abundantly expressed in the lung, making them strong candidates as repurposed drugs for chronic airway disorders and acute lung injury. [Display omitted]
ISSN:2211-3835
2211-3843
DOI:10.1016/j.apsb.2022.06.003