Microwave-assisted polyol synthesis of carbon nitride dots from folic acid for cell imaging

A green, one-step microwave-assisted polyol synthesis was employed to prepare blue luminescent carbon nitride dots (CNDs) using folic acid molecules as both carbon and nitrogen sources. The as-prepared CNDs had an average size of around 4.51 nm and could be well dispersed in water. Under excitation...

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Bibliographic Details
Published in:International journal of nanomedicine 2014-01, Vol.9 (Issue 1), p.5071-5078
Main Authors: Guan, Weiwei, Gu, Wei, Ye, Ling, Guo, Chenyang, Su, Su, Xu, Pinxiang, Xue, Ming
Format: Article
Language:English
Subjects:
Animals
Carbon
carbon nitride dots (CNDs)
cell imaging
Cell Line, Tumor
Cell Survival - drug effects
Diagnostic imaging
Efficiency
Fluorescent Dyes - chemistry
Fluorescent Dyes - toxicity
Folic acid
Folic Acid - chemistry
Fourier transforms
Graphene
Hemodialysis
Methods
Microwaves
Nanoparticles
Nanotechnology
Nitriles - chemical synthesis
Nitriles - chemistry
Nitrogen
Optical Imaging
Original Research
photoluminescence
Polymers - chemistry
Polyols
Properties
Quantum dots
Quantum Dots - chemistry
Quantum Dots - toxicity
Rats
Spectrum analysis
Sulfur
Transmission electron microscopy
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Summary:A green, one-step microwave-assisted polyol synthesis was employed to prepare blue luminescent carbon nitride dots (CNDs) using folic acid molecules as both carbon and nitrogen sources. The as-prepared CNDs had an average size of around 4.51 nm and could be well dispersed in water. Under excitation at 360 nm, the CNDs exhibited a strong blue luminescence and the quantum yield was estimated to be 18.9%, which is greater than that of other reported CNDs. Moreover, the CNDs showed low cytotoxicity and could efficiently label C6 glioma cells, demonstrating their potential in cell imaging.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/ijn.s68575