Elevated Mortality Risk from CRKp Associated with Comorbidities: Systematic Review and Meta-Analysis

Carbapenem-resistant Klebsiella pneumoniae has become a public health problem with therapeutic limitations and high mortality associated with comorbidities. Methods: This is a systematic review and meta-analysis with a search in PubMed, SciELO, and Lilacs. Ten articles were selected, considering coh...

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Bibliographic Details
Published in:Antibiotics (Basel) 2022-06, Vol.11 (7), p.874
Main Authors: Gonçalves Barbosa, Lucas Candido, Silva E Sousa, José Arthur, Bordoni, Graziela Picciola, Barbosa, Gabriel de Oliveira, Carneiro, Lilian Carla
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
carbapenems
Cardiovascular disease
Cardiovascular diseases
Comorbidity
Coronary artery disease
Diabetes
Diabetes mellitus
Enzymes
Fatalities
health public
Heart diseases
Hospitals
Kidney diseases
Kidneys
Klebsiella
Klebsiella pneumoniae
Liver
Liver diseases
Lung diseases
Meta-analysis
Microorganisms
Mortality
Mortality risk
Nosocomial infections
Pathogens
Pneumonia
Public health
Review
Risk
Statistical analysis
Systematic review
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Summary:Carbapenem-resistant Klebsiella pneumoniae has become a public health problem with therapeutic limitations and high mortality associated with comorbidities. Methods: This is a systematic review and meta-analysis with a search in PubMed, SciELO, and Lilacs. Ten articles were selected, considering cohort, case-control, and cross-sectional studies. Tests for proportions and relative risk of mortality were performed, considering a 5% threshold for significance. Statistical analyses were performe dusing Rstudio® software, version 4.0.2 of Ross Ihaka and Robert Genleman in Auckland, New Zealand. Results: Klebsiella pneumoniae, associated with chronic kidney disease, was responsible for 26%/258 deaths, chronic lung disease 28%/169, diabetes 31%/185, liver disease 15%/262, and heart disease 51%/262 deaths. Carbapenem-resistant Klebsiella pneumoniae associated with chronic kidney disease was responsible for 49%/83 deaths, with diabetes 29%/73, and with liver disease 33%/73 deaths. The risk of death from carbapenem-resistant Klebsiella pneumoniae was twice as high as the number of deaths associated with carbapenem-sensitive Klebsiella pneumoniae, RR = 2.07 (p < 0.00001). Conclusions: The present study showed an increase in mortality from carbapenem-resistant Klebsiella pneumoniae when associated with comorbidities.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11070874