Sex differences in gene regulation in the dorsal root ganglion after nerve injury

Pain is a subjective experience derived from complex interactions among biological, environmental, and psychosocial pathways. Sex differences in pain sensitivity and chronic pain prevalence are well established. However, the molecular basis underlying these sex dimorphisms are poorly understood part...

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Bibliographic Details
Published in:BMC genomics 2019-02, Vol.20 (1), p.147-18, Article 147
Main Authors: Stephens, Kimberly E, Zhou, Weiqiang, Ji, Zhicheng, Chen, Zhiyong, He, Shaoqiu, Ji, Hongkai, Guan, Yun, Taverna, Sean D
Format: Article
Language:English
Subjects:
Analysis
Animals
Chronic pain
Clinical trials
Dorsal root ganglion
Female
Ganglia, Spinal - metabolism
Ganglia, Spinal - pathology
Ganglion cysts
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Genes
Genetic regulation
Genetic research
Male
Nerve injury
Peripheral Nerve Injuries - etiology
Peripheral Nerve Injuries - metabolism
Peripheral Nerve Injuries - pathology
Peripheral nervous system
Quality of life
Rats
RNA
RNA-seq
Sex differences
Sex differences (Biology)
Sex differences (Psychology)
Sex Factors
Transcriptome
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Summary:Pain is a subjective experience derived from complex interactions among biological, environmental, and psychosocial pathways. Sex differences in pain sensitivity and chronic pain prevalence are well established. However, the molecular basis underlying these sex dimorphisms are poorly understood particularly with regard to the role of the peripheral nervous system. Here we sought to identify shared and distinct gene networks functioning in the peripheral nervous systems that may contribute to sex differences of pain in rats after nerve injury. We performed RNA-seq on dorsal root ganglia following chronic constriction injury of the sciatic nerve in male and female rats. Analysis from paired naive and injured tissues showed that 1513 genes were differentially expressed between sexes. Genes which facilitated synaptic transmission in naïve and injured females did not show increased expression in males. Appreciating sex-related gene expression differences and similarities in neuropathic pain models may help to improve the translational relevance to clinical populations and efficacy of clinical trials of this major health issue.
ISSN:1471-2164
1471-2164
DOI:10.1186/s12864-019-5512-9