Aging-related aneuploidy is associated with mitochondrial imbalance and failure of spindle assembly

Despite aging is closely linked to increased aneuploidy in the oocytes, the mechanism of how aging affects aneuploidy remains largely elusive. Here, we applied single-cell parallel methylation and transcriptome sequencing (scM&T-seq) data from the aging mouse oocyte model to decode the genomic l...

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Bibliographic Details
Published in:Cell death discovery 2023-07, Vol.9 (1), p.235-235, Article 235
Main Authors: Zhang, Fa-Li, Li, Wei-Dong, Zhu, Ke-Xin, Zhou, Xu, Li, Lan, Lee, Tin-Lap, Shen, Wei
Format: Article
Language:English
Subjects:
631/136/2434/1706
631/136/7
Aging
Aneuploidy
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Cycle Analysis
Correlation analysis
DNA methylation
Life Sciences
Mitochondria
Oocytes
Receptor mechanisms
Stem Cells
Transcriptomes
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Summary:Despite aging is closely linked to increased aneuploidy in the oocytes, the mechanism of how aging affects aneuploidy remains largely elusive. Here, we applied single-cell parallel methylation and transcriptome sequencing (scM&T-seq) data from the aging mouse oocyte model to decode the genomic landscape of oocyte aging. We found a decline in oocyte quality in aging mice, as manifested by a significantly lower rate of first polar body exclusion ( P  
ISSN:2058-7716
2058-7716
DOI:10.1038/s41420-023-01539-2