Antiangiogenic and antiapoptotic effects of green-synthesized zinc oxide nanoparticles using Sargassum muticum algae extraction

Background Algae are one of the natural materials used to green synthesis of nanoparticles. This method leads to minimize the toxicity of the chemical materials used to nanoparticle synthesis. Methods In this study, zinc oxide nanoparticles (ZnO NPs) synthesized by Sargassum muticum algae extraction...

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Bibliographic Details
Published in:Cancer nanotechnology 2018, Vol.9 (1), p.3-16, Article 3
Main Authors: Sanaeimehr, Zahra, Javadi, Iraj, Namvar, Farideh
Format: Article
Language:English
Subjects:
Algae
Angiogenesis
Antiangiogenics
Antioxidant
Apoptosis
Assaying
Biochemistry
Biomedical Engineering and Bioengineering
Cancer
Cancer Research
Chemical synthesis
Chemistry and Materials Science
Flowcytometry
Liver
Liver cancer
Materials Science
Nanoparticles
Nanotechnology
Toxicity
Zinc oxide
Zinc oxide nanoparticles
Zinc oxides
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Summary:Background Algae are one of the natural materials used to green synthesis of nanoparticles. This method leads to minimize the toxicity of the chemical materials used to nanoparticle synthesis. Methods In this study, zinc oxide nanoparticles (ZnO NPs) synthesized by Sargassum muticum algae extraction used to evaluate its cytotoxicity and apoptotic properties on human liver cancer cell line (HepG2). Results Trypan blue assay results demonstrate a concentration-dependent decrease in cell viability and MTT assay shows increased growth inhibition in time and dose-dependent manner. In addition, CAM assay confirmed the ability of ZnO NPs to inhibit angiogenesis, but chick morphology (both the CR and weight) was not changed. Apoptotic tests (annexin V/PI and AO/PI) show that green-synthesized ZnO NPs induce apoptosis in all three time points (24, 48 and 72h). Conclusions Our results confirm the beneficial cytotoxic effects of green-synthesized ZnO NPs on Human liver cancer cell. This nanoparticle decreased angiogenesis and induces apoptosis, so we conclude that these nanoparticles can be used as a supplemental drug in cancer treatments.
ISSN:1868-6958
1868-6966
DOI:10.1186/s12645-018-0037-5