Real-world patterns of pegloticase use for treatment of gout: descriptive multidatabase cohort study

• Published in: BMJ open 2020-12, Vol.10 (12), p.e041167
• Main Authors: Chen, Sarah K, Liu, Jun, Kim, Seoyoung C
• Format: Article
• Language: English
• Subjects: Age; Anaphylaxis; Arthritis; Cardiovascular disease; Codes; Cohort analysis; Cohort Studies; Diabetes; Drug dosages; Epidemiology; Female; general medicine (see internal medicine); Gout - drug therapy; Gout - epidemiology; Gout Suppressants - adverse effects; Heart failure; Humans; Hypertension; Insurance claims; Kidney diseases; Laboratories; Male; Middle Aged; Patients; Polyethylene Glycols - adverse effects; Prescription drugs; Retrospective Studies; Rheumatism; Rheumatology; Urate Oxidase - adverse effects; Uric Acid
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2020-041167

ObjectivePegloticase is used in severe refractory gout or in cases of intolerance to other urate-lowering therapies. We sought to evaluate the patterns of pegloticase use in the USA and the incidence of safety outcomes.MethodsWe conducted a retrospective descriptive study using data from two US commercial insurance claims databases (2010–2018). We identified new initiators of pegloticase with ≥1 gout diagnosis code in the 365-day baseline period prior to pegloticase initiation. We measured the number and duration of pegloticase infusions. We assessed the risk of anaphylaxis or anaphylactoid reactions, cardiovascular events, including myocardial infarction or stroke, and hospitalisation for heart failure (new onset or exacerbations) while undergoing pegloticase therapy.ResultsAmong 2.9 million patients with ≥1 diagnosis of gout, we identified only 483 (179 in Optum and 304 in MarketScan) pegloticase initiators. The mean age and % female was 55.6 years, 10.9% for MarketScan and 60.6 years and 17.3% for Optum. Hypertension was present in up to 85%, diabetes mellitus in 38%, chronic kidney disease in 46% and heart failure in 21% of the patients. The median number of infusions was four and the duration of therapy was 3 months. During the mean 0.5-year follow-up time on pegloticase, there were 3 (0.6%) anaphylaxis, 7 (1.4%) composite cardiovascular, 31 (6.4%) heart failure hospitalisations and 3 (0.6%) deaths.ConclusionPegloticase is rarely used in gout, and the median duration of pegloticase therapy was 3 months. There were few anaphylaxis events captured in this claims-based study, while heart failure hospitalisations were common.