Association between auditory P300, psychopathology, and memory function in drug-naïve schizophrenia

Abstract The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naïve patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale—Revised were administered. Auditory event-related potentials e...

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Bibliographic Details
Published in:The Kaohsiung journal of medical sciences 2014-03, Vol.30 (3), p.133-138
Main Authors: Chang, Wei-Hung, Chen, Kao-Chin, Yang, Yen-Kuang, Chen, Po-See, Lu, Ru-Band, Yeh, Tzung-Lieh, Wang, Carol Sheei-Meei, Lee, I-Hui
Format: Article
Language:English
Subjects:
Adolescent
Adult
Default model network
Drug-naïve schizophrenia
Evoked Potentials - physiology
Female
Humans
Internal Medicine
Male
Memory - physiology
P300
Psychopathology
Schizophrenia - physiopathology
Visual memory
Young Adult
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Summary:Abstract The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naïve patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale—Revised were administered. Auditory event-related potentials elicited by an oddball paradigm were obtained. After controlling for age, sex, the results showed a statistically significant negative correlation between the total PANSS score and P300 amplitude at the parietal position ( r  = −0.66, p  
ISSN:1607-551X
2410-8650
DOI:10.1016/j.kjms.2013.10.003