Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC50, 32.5 µmol/L) in the c...

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Bibliographic Details
Published in:Acta pharmaceutica Sinica. B 2014-04, Vol.4 (2), p.141-145
Main Authors: Uchida, Ryuji, Ishikawa, Seiko, Tomoda, Hiroshi
Format: Article
Language:English
Subjects:
2-Hydroxytyrosol
B16 melanoma cells
Melanine formation
Metarhizium sp
Original
Tyrosinase inhibitor
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Summary:2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC50, 32.5 µmol/L) in the cell-free extract of B16 melanoma cells and α-melanocyte stimulating hormone (α-MSH)-stimulated melanin formation in intact B16 melanoma cells.
ISSN:2211-3835
2211-3843
DOI:10.1016/j.apsb.2013.12.008