The role of tumor-derived extracellular vesicles containing noncoding RNAs in mediating immune cell function and its implications from bench to bedside

Extracellular vesicles (EVs) are membrane-encapsulated vesicles released by almost all cell types, which participate in intercellular communication by delivering different types of molecular cargoes, such as non-coding RNAs (ncRNAs). Accumulating evidence suggests that tumor-derived EVs act as a bri...

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Bibliographic Details
Published in:Pharmacological research 2023-05, Vol.191, p.106756-106756, Article 106756
Main Authors: Liu, Chen-Guang, Chen, Jun, Goh, Robby Miguel Wen-Jing, Liu, Yu-Xuan, Wang, Lingzhi, Ma, Zhaowu
Format: Article
Language:English
Subjects:
Cancer therapy
Cell Communication
Extracellular vesicles
Extracellular Vesicles - metabolism
Immunity, Innate
Non-coding RNAs
RNA, Untranslated - genetics
RNA, Untranslated - metabolism
Tumor immunity
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Summary:Extracellular vesicles (EVs) are membrane-encapsulated vesicles released by almost all cell types, which participate in intercellular communication by delivering different types of molecular cargoes, such as non-coding RNAs (ncRNAs). Accumulating evidence suggests that tumor-derived EVs act as a bridge for intercellular crosstalk between tumor cells and surrounding cells, including immune cells. Tumor-derived EVs containing ncRNAs (TEV-ncRNAs) mediate intercellular crosstalk to manipulate immune responses and affect the malignant phenotypes of cancer cells. In this review, we summarize the double-edged roles and the underlying mechanisms of TEV-ncRNAs in regulating innate and adaptive immune cells. We also highlight the advantages of using TEV-ncRNAs in liquid biopsies for cancer diagnosis and prognosis. Moreover, we outline the use of engineered EVs to deliver ncRNAs and other therapeutic agents for cancer therapy. [Display omitted]
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2023.106756