miRNAs in Cancer (Review of Literature)

MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the course of processes of fundamental importance for the proper functioning of the organism. These processes include cell divisio...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-03, Vol.23 (5), p.2805
Main Authors: Smolarz, Beata, Durczyński, Adam, Romanowicz, Hanna, Szyłło, Krzysztof, Hogendorf, Piotr
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Biosynthesis
Blood vessels
Breast cancer
cancer
Carcinogenesis - genetics
Cell differentiation
Cell division
Colorectal cancer
diagnosis
DNA methylation
Epigenetics
Gene expression
Genes
Humans
Literature reviews
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Neoplasms - genetics
Neoplasms - therapy
Oncogenes
Physiology
Post-transcription
Review
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Summary:MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the course of processes of fundamental importance for the proper functioning of the organism. These processes include cell division, proliferation, differentiation, cell apoptosis and the formation of blood vessels. Altered expression of individual miRNAs has been shown in numerous cancers, which may indicate the oncogenic or suppressor potential of the molecules in question. This paper discusses the current knowledge about the possibility of using miRNA as a diagnostic marker and a potential target in modern anticancer therapies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23052805