Estabelecimento de condições para ensaio de dissolução de cápsulas de cinarizina empregando planejamento fatorial

This work describes the establishment of dissolution test conditions for 75 mg cinnarizine capsules using a multivariate approach. A 2³ full factorial design was carried out to achieve the best conditions and HCl 0.1 mol L-1 as dissolution medium, basket as apparatus at 100 rpm and collect time at 3...

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Bibliographic Details
Published in:Química Nova 2011-01, Vol.34 (3), p.455-461
Main Authors: Patrícia Alves Franco Gehring, Olímpia Maria Martins Santos, Gislaine Ribeiro Pereira, Magali Benjamim de Araújo, Rudy Bonfilio
Format: Article
Language:English
Subjects:
2³ full factorial design
cinnarizine
dissolution test
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Summary:This work describes the establishment of dissolution test conditions for 75 mg cinnarizine capsules using a multivariate approach. A 2³ full factorial design was carried out to achieve the best conditions and HCl 0.1 mol L-1 as dissolution medium, basket as apparatus at 100 rpm and collect time at 30 min were considered adequate. The quantification was carried out by spectrophotometry at 251 nm. Both dissolution procedure and analytical method were validated and all parameters were within the acceptable limits. Since there is no official monograph for this pharmaceutical product, this dissolution test could be applied for quality control routine.
ISSN:1678-7064
DOI:10.1590/S0100-40422011000300017