Reflections on the CODES trial for adults with dissociative seizures: what we found and considerations for future studies

The COgnitive behavioural therapy versus standardised medical care for adults with Dissociative non-Epileptic Seizures multicentre randomised controlled trial is the largest, fully-powered study to test the clinical and cost-effectiveness of a psychotherapeutic intervention in this population. We al...

Full description

Saved in:
Bibliographic Details
Published in:BMJ neurology open 2024-06, Vol.6 (1), p.e000659-e000659
Main Authors: Goldstein, Laura H, Stone, Jon, Reuber, Markus, Landau, Sabine, Robinson, Emily J, Carson, Alan, Medford, Nick, Chalder, Trudie
Format: Article
Language:English
Subjects:
Anxiety
Behavior modification
Clinical outcomes
Convulsions & seizures
Cost analysis
Epilepsy
Intervention
Patients
Quality of life
Questionnaires
RANDOMISED TRIALS
Review
Therapy
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The COgnitive behavioural therapy versus standardised medical care for adults with Dissociative non-Epileptic Seizures multicentre randomised controlled trial is the largest, fully-powered study to test the clinical and cost-effectiveness of a psychotherapeutic intervention in this population. We also explored predictors or moderators of outcomes and investigated mechanisms of change in therapy. In this current review of findings, we discuss issues related to the design of the trial and consider the study’s nested qualitative studies which were undertaken not only to shed light on the original research questions but to provide insights and recommendations for other researchers in the field of functional neurological disorder. Finally, we consider issues relating to the possible clinical application of our study findings.
ISSN:2632-6140
2632-6140
DOI:10.1136/bmjno-2024-000659