The potential of mangosteen ( Garcinia mangostana ) peel extract, combined with demineralized freeze-dried bovine bone xenograft, to reduce ridge resorption and alveolar bone regeneration in preserving the tooth extraction socket

• Published in: The journal of Indian Prosthodontic Society 2017-07, Vol.17 (3), p.282-288
• Main Authors: Kresnoadi, Utari, Ariani, Maretaningtias Dwi, Djulaeha, Eha, Hendrijantini, Nike
• Format: Article
• Language: English
• Subjects: Alcohol; Alveolar bone; Antioxidants; Bone growth; Bone morphogenetic protein 2; Bone morphogenetic proteins; Bone resorption; Cytokines; Dental implants; Dentistry; Food; Free radicals; Gene expression; graft materials; Inflammation; Kinases; Ligands; Mangosteen; mangosteen peel extracts; Medicine; NF-κB protein; nuclear factor κβ; Original; Osteoblasts; Osteoclasts; Osteoclasts (Biology); Polyethylene glycol; preserved tooth extraction socket; Proteins; receptor activator of nuclear factor-κβ ligand expressions; Regeneration; Teeth; Tooth extractions; TRANCE protein; Transplants & implants; Tumor necrosis factor-TNF; Xenografts; Xenotransplantation
• ISSN: 0972-4052; 1998-4057
• DOI: 10.4103/jips.jips_64_17

Following the extraction of a tooth, bone resorption can cause significant problems for a subsequent denture implant and restorative dentistry. Thus, the tooth extraction socket needs to be maintained to reduce the chance of any alveolar ridge bone resorption. The objective of this study is to determine whether the administration of mangosteen peel extracts (MPEs), combined with demineralized freeze-dried bovine bone xenograft (DFBBX) materials for tooth extraction socket preservation, could potentially reduce inflammation by decreased the expression of nuclear factor κβ (NfKb) and receptor activator of nuclear factor-κβ ligand (RANKL), to inhibit alveolar bone resorption, and increased of bone morphogenetic protein-2 (BMP2) expressions to accelerate alveolar bone regeneration. This study consists of several stages. First, a dosage of MPE combined with graft materials was applied to a preserved tooth extraction socket of a . Second, the was examined using immune histochemical expression of NfKb, RANKL, BMP2, as well as histology of osteoblasts and osteoclasts. The research was statistically analyzed, using an analysis of variance test and Tukey honest significant difference test. The results of this research were that it was determined that MPEs combined with graft materials on a preserved tooth extraction socket can reduce NfKb, RANK, and osteoclasts also increase of BMP2 and osteoblast. The induction of MPEs and DFBBX is effective in reducing inflammation, lowering osteoclasts, decreasing alveolar bone resorption, and also increasing BMP2 expression and alveolar bone regeneration.