Association between 25-OH Vitamin D Deficiency and COVID-19 Severity in Pregnant Women

Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for S...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-12, Vol.23 (23), p.15188
Main Authors: Vásquez-Procopio, Johana, Torres-Torres, Johnatan, Borboa-Olivares, Hector, Sosa, Salvador Espino Y, Martínez-Portilla, Raigam Jafet, Solis-Paredes, Mario, Tolentino-Dolores, Mari-Cruz, Helguera-Repetto, Addy Cecilia, Marrufo-Gallegos, Karla Cecilia, Missirlis, Fanis, Perichart-Perera, Otilia, Estrada-Gutierrez, Guadalupe
Format: Article
Language:English
Subjects:
Asymptomatic
Calciferol
Communication
Coronaviruses
COVID-19
COVID-19 - complications
Cytokines
Ethnicity
Female
Gestational age
Gestational diabetes
Health care
Hospitalization
Humans
Hypertension
Immune system
Infections
Observational studies
Population studies
Pregnancy
Pregnancy Complications
Premature birth
Public health
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Tumor necrosis factor-TNF
Vitamin D
Vitamin D Deficiency
Vitamin deficiency
Womens health
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Summary:Evidence from studies in the general population suggests an association between vitamin D insufficiency/deficiency and COVID-19 susceptibility and disease severity. The present study was performed on 165 third-trimester pregnant women at the time of delivery. Seventy-nine women tested negative for SARS-CoV-2. From 86 women testing positive, 32 were asymptomatic, 44 presented a mild form of the disease, and 10 experienced severe symptoms. Serum 25-OH vitamin D levels were measured on blood samples collected on admission. Low vitamin D levels were detected in symptomatic but not asymptomatic COVID-19 patients compared to healthy women ( = 0.0227). In addition, 20 (45.4%) pregnant women in the mild COVID-19 group and 6 (60%) in the severe group were vitamin D deficient ( = 0.030). On the other hand, lasso regression analysis showed that 25-OH vitamin D deficiency is an independent predictor of severe COVID-19 with an odds ratio (OR) of 5.81 (95% CI: 1.108-30.541; = 0.037). These results show the relationship between vitamin D deficiency in pregnant women and the severity of COVID-19 infection and support the recommendation to supplement with vitamin D to avoid worse COVID-19 outcomes during pregnancy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232315188