African histoplasmosis: report of the first case in Brazil and treatment with itraconazole Histoplasmose africana: relato do primeiro caso no Brasil e tratado pelo itraconazol

• Published in: Revista do Instituto de Medicina Tropical de São Paulo 1993-06, Vol.35 (3), p.295-299
• Main Authors: Leonardo Abrucio Neto, Maria Denise Fonseca Takahashi, Alberto Salebian, Luiz Carlos Cucé
• Format: Article
• Language: English
• Subjects: African Histoplasmosis; Histoplasma capsulatum var. duboisii; Itraconazole
• ISSN: 0036-4665; 1678-9946
• DOI: 10.1590/S0036-46651993000300013

We report the first case of African histoplasmosis diagnosed in Brazil. The patient was an immigrant from Angola who had come to Brazil six months after the appearance of the skin lesion. The skin of the right retroauricular area was the only site of involvement. The diagnosis was established by direct mycologic examination, culture and by histopathologic examination of the lesion. The patient was successfully treated with Itraconazole 100mg a day for 52 days. No recurrent skin lesions were observed during the ten month follow-up period.Relata-se o primeiro caso de histoplasmose africana diagnosticado em nosso meio, em indivíduo angolano que imigrou para o Brasil seis meses após o início das lesões. Quadro clínico de forma localizada exclusivamente na pele na região retro auricular direita. O diagnóstico foi estabelecido através do exame micológico direto, cultura e exame anátomo-patológico. Houve sucesso terapêutico com a administração de itraconazol, na dose de 100mg/dia durante 52 dias. Não houve recidiva do quadro cutâneo no seguimento clínico do doente após 10 meses de interrupção do tratamento.