Predictive factors and impact of full donor T-cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation

• Published in: Haematologica (Roma) 2007-07, Vol.92 (7), p.1004-1006
• Main Authors: Mohty, Mohamad, Avinens, Odile, Faucher, Catherine, Viens, Patrice, Blaise, Didier, Eliaou, Jean-Francois
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation - methods; Humans; Kinetics; Male; Middle Aged; Myeloproliferative Disorders - diagnosis; Predictive Value of Tests; Prognosis; Recurrence; Siblings; T-Lymphocytes; Transplantation Chimera; Transplantation Conditioning - methods; Transplantation, Homologous
• ISSN: 0390-6078; 1592-8721
• DOI: 10.3324/haematol.10971

* Unite de Transplantation et de Therapie Cellulaire (UTTC), Institut Paoli-Calmettes, Marseille, France ° Université de la Méditerranée, Faculté de Médecine, Marseille, France; # INSERM, UMR 599, Marseille, France; @ Laboratoire d’Immunologie, Hopital Saint-Eloi, CHU de Montpellier, Montpellier, France; ^ Département d’Oncologie Médicale, Institut Paoli-Calmettes, Marseille, France DB and JFE share senior authorship Correspondence: Mohamad Mohty, M.D., Ph.D., Institut Paoli-Calmettes, 232 Bd. Ste Marguerite, F-13273 Marseille Cedex 09, France. Phone: international [phone]; Fax: international [phone]. E-Mail: mohtym{at}marseille.fnclcc.fr This study investigated the kinetics of CD3+-T cell chimerism (TCC) in 102 patients receiving reduced intensity conditioning allogeneic stem cell transplantation (RIC-allo-SCT) from an HLA-identical sibling. Patients with full donor TCC at day 30 had a higher incidence of grade 2–4 acute GVHD compared to patients in mixed TCC (cumulative-incidence, 61% vs. 35%; p =0.01). The delayed establishment of full donor TCC in myeloid malignancies was associated with a higher incidence of relapse (40% vs. 0; p =0.002), suggesting that monitoring of the kinetics of TCC is mandatory after RIC-allo-SCT.