Epidemiology of potential drug-drug interactions in elderly population admitted to critical care units of Peshawar, Pakistan

Aging population, is a reality in many countries because of improvement in the health care, patient safety and other supplemental factors. Pharmacotherapy in this population must be evaluated due to their higher susceptibility to adverse drug outcomes, like potential drug-drug interactions (PDDIs)....

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Bibliographic Details
Published in:BMC pharmacology & toxicology 2018-12, Vol.19 (1), p.85-6, Article 85
Main Authors: Shakeel, Faisal, Aamir, Muhammad, Khan, Ahmad Farooq, Khan, Tayyiba Nader, Khan, Samiullah
Format: Article
Language:English
Subjects:
Age
Aging
Clinical medicine
Critical care
Developing countries
Documentation
Drug therapy
Epidemiology
Geriatrics
Hospitals
Intensive care
LDCs
Older people
Patient safety
Patients
Pharmacodynamics
Pharmacology
Polypharmacy
Population
Population studies
Potential drug-drug interactions
Statins
Statistical analysis
Variance analysis
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Summary:Aging population, is a reality in many countries because of improvement in the health care, patient safety and other supplemental factors. Pharmacotherapy in this population must be evaluated due to their higher susceptibility to adverse drug outcomes, like potential drug-drug interactions (PDDIs). Research in this regard is limited particularly in developing countries. The aim of the study was to evaluate the prevalence and associated factors in this population. The multicentered study evaluated the prevalence of potential drug-drug interactions and associated factors in elderly population at critical care units in Peshawar, Pakistan. Potential drug-drug interactions were evaluated using Micromedex DrugReax, while statistical analysis was performed using SPSS. A total of 70.17% elderly patients were observed to have at least one PDDI. A significant association was observed between presence of PDDIs and number of prescribed drugs, duration of stay and age (p 
ISSN:2050-6511
2050-6511
DOI:10.1186/s40360-018-0276-4