Continuous intake of quercetin-rich onion powder may improve emotion but not regional cerebral blood flow in subjects with cognitive impairment

Depression in later life is associated with dementia. Changes in motivated behavior are an important mechanism contributing to dysfunctional cognitive control in depression. Although continuous intake of quercetin-rich onion suppresses cognitive decline in aged people by improving their emotional co...

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Bibliographic Details
Published in:Heliyon 2023-08, Vol.9 (8), p.e18401, Article e18401
Main Authors: Hayashi, Yuichi, Hyodo, Fuminori, Tana, Nakagawa, Kiyomi, Ishihara, Takuma, Matsuo, Masayuki, Shimohata, Takayoshi, Nishihira, Jun, Kobori, Masuko, Nakagawa, Toshiyuki
Format: Article
Language:English
Subjects:
Alzheimer's disease
Behavioral and psychological symptoms of dementia
blood flow
brain
cognition
cognitive disorders
dementia
Depression
diet
head
homeostasis
Mild cognitive impairment
onions
people
quercetin
Redox
tomography
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Summary:Depression in later life is associated with dementia. Changes in motivated behavior are an important mechanism contributing to dysfunctional cognitive control in depression. Although continuous intake of quercetin-rich onion suppresses cognitive decline in aged people by improving their emotional condition, the effect of quercetin-rich onion on emotional condition in people living with cognitive impairment remains unclear. In this randomized, double-blind, placebo-controlled study of subjects with cognitive impairment, we found that subjects wrote more adjectives and adverbs per sentence on the Mini-Mental State Examination after intake of quercetin-rich onion powder than before intake, although regional cerebral blood flow on n-isopropyl-4-[123]iodoamphetamine hydrochloride single-photon emission computed tomography was not changed. In the EPM, mice that had received a quercetin-supplemented chow diet made a significantly increased number of exploratory head dips from the open arms of the maze. Moreover, the 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl decay rate, reflecting redox activity, was increased in mice fed a quercetin-added diet. These results indicate that quercetin-rich onion may affect motivated behavior in subjects with cognitive impairment, for whom quercetin intake may preserve redox homeostasis in the brain.
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e18401