The Scope of Kidney Affection in Monoclonal Gammopathies at All Levels of Clinical Significance

Multiple myeloma (MM) is one of the most important clonal malignant plasma cell disorders and renal involvement is associated with poor prognosis. Although there are several reasons for renal impairment in MM, the main cause is the toxic effects of monoclonal proteins. Although cast nephropathy is t...

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Bibliographic Details
Published in:Turkish journal of haematology 2017-12, Vol.34 (4), p.282-288
Main Authors: Mehtat Ünlü, Şadiye, Özsan, Hayri, Sarıoğlu, Sülen
Format: Article
Language:English
Subjects:
Biopsy
Bone marrow
cast nephropathy
Clinical significance
Immunoglobulins
kidney
Kidney diseases
monoclonal gammopathy of renal significance
Multiple myeloma
Nephrology
Patients
Plasma
plasma cell disorders
Proteins
renal involvement
Review
Tıp
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Summary:Multiple myeloma (MM) is one of the most important clonal malignant plasma cell disorders and renal involvement is associated with poor prognosis. Although there are several reasons for renal impairment in MM, the main cause is the toxic effects of monoclonal proteins. Although cast nephropathy is the best known and unchallenged diagnosis for hematologists and pathologists, the renal effects of monoclonal gammopathy can be various. Monoclonal gammopathy of renal significance was proposed by the International Kidney and Monoclonal Gammopathy Research Group for renal lesions in monoclonal gammopathy in recent years. Renal lesions in monoclonal gammopathy can be grouped as follows: light chain (cast) nephropathy, acute tubular injury/necrosis, tubulointerstitial nephritis, amyloidosis, monoclonal Ig deposition diseases, immunotactoid glomerulopathy, type I cryoglobulinemia, proliferative glomerulonephritis with monoclonal IgG deposits, C3 glomerulopathy with monoclonal gammopathy, and crystal-storing histiocytosis, considering the previous and new terminology. In this study, renal involvement of monoclonal gammopathies, in terms of previous and new terminology, was reviewed.
ISSN:1300-7777
1308-5263
DOI:10.4274/tjh.2017.0197