The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens

The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of more than 100 c...

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Bibliographic Details
Published in:Genome Biology 2019-01, Vol.20 (1), p.1-1, Article 1
Main Authors: Repana, Dimitra, Nulsen, Joel, Dressler, Lisa, Bortolomeazzi, Michele, Venkata, Santhilata Kuppili, Tourna, Aikaterini, Yakovleva, Anna, Palmieri, Tommaso, Ciccarelli, Francesca D
Format: Article
Language:English
Subjects:
Cancer
Cancer genes
Cancer genomics screens
Cancer heterogeneity
Databases, Genetic
Datasets
Genes
Genes, Neoplasm
Genetic Heterogeneity
Genomes
Genomics
Humans
miRNA
Protein expression
Protein interaction
Proteins
Quarks
Systems-level properties
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Summary:The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of more than 100 cancer types from 34,905 cancer donors and multiple primary sites. This represents a more than 1.5-fold content increase compared to the previous version. NCG also annotates properties of cancer genes, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, and protein function and essentiality. NCG is accessible at http://ncg.kcl.ac.uk/ .
ISSN:1474-760X
1474-7596
1474-760X
DOI:10.1186/s13059-018-1612-0