Aldehyde dehydrogenase 2 overexpression inhibits neuronal apoptosis after spinal cord ischemia/reperfusion injury

Aldehyde dehydrogenase 2（ALDH2）is an important factor in inhibiting oxidative stress and has been shown to protect against renal ischemia/reperfusion injury.Therefore,we hypothesized that ALDH_2 could reduce spinal cord ischemia/reperfusion injury.Spinal cord ischemia/reperfusion injury was induced...

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Bibliographic Details
Published in:Neural regeneration research 2017-07, Vol.12 (7), p.1166-1171
Main Authors: Liu, Xing-Zhen, Sun, Xin, Shen, Kang-Ping, Jin, Wen-Jie, Fu, Zhi-Yi, Tao, Hai-Rong, Xu, Zhi-Xing
Format: Article
Language:English
Subjects:
Abdomen
Acids
Alcohol
Aldehydes
ALDH2
Apoptosis
Coronary vessels
Dehydrogenases
Enzymes
Ethanol
Health aspects
Ischemia
Laboratory animals
Lipid peroxidation
Metabolism
Metabolites
nerve regeneration
spinal cord ischemia/reperfusion injury
aldehyde dehydrogenase 2
alcohol
apoptosis
oxidative stress
terminal deoxynucleotidyl transferase dUTP nick-end labeling
neural regeneration
Oxidative stress
Protein expression
Proteins
Risk factors
Spinal cord injuries
Statistical analysis
Surgery
Veins & arteries
乙醛脱氢酶
基因
神经元
细胞凋亡
缺血/再灌注损伤
缺血再灌注损伤
脊髓
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Summary:Aldehyde dehydrogenase 2（ALDH2）is an important factor in inhibiting oxidative stress and has been shown to protect against renal ischemia/reperfusion injury.Therefore,we hypothesized that ALDH_2 could reduce spinal cord ischemia/reperfusion injury.Spinal cord ischemia/reperfusion injury was induced in rats using the modified Zivin＇s method of clamping the abdominal aorta.After successful model establishment,the agonist group was administered a daily consumption of 2.5%alcohol.At 7 days post-surgery,the Basso,Beattie,and Bresnahan score significantly increased in the agonist group compared with the spinal cord ischemia/reperfusion injury group.ALDH_2expression also significantly increased and the number of apoptotic cells significantly decreased in the agonist group than in the spinal cord ischemia/reperfusion injury group.Correlation analysis revealed that ALDH_2 expression negatively correlated with the percentage of TUNEL-positive cells（r=-0.485,P〈0.01）.In summary,increased ALDH_2 expression protected the rat spinal cord against ischemia/reperfusion injury by inhibiting apoptosis.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.211198