Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach

Ferroptosis, a new type of non-apoptotic cell death modality, is different from other modes of cell death and has been primarily found in tumor cells. Previous studies have reported that ferroptosis can be triggered by specific modulators (e.g., drugs, nutrients, and iron chelators), leading to incr...

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Published in:Antioxidants 2022-07, Vol.11 (8), p.1504
Main Authors: Chen, Heshu, Wang, Chenyu, Liu, Zemin, He, Xinmiao, Tang, Wenjie, He, Liuqin, Feng, Yanzhong, Liu, Di, Yin, Yulong, Li, Tiejun
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Cancer
Cell death
Chelating agents
Enzymes
Ferroptosis
Glutathione peroxidase
Homeostasis
Inflammation
Iron
Lipid peroxidation
Lipids
Mammals
Mitochondria
Observations
Oxidative stress
Proteins
Reactive oxygen species
Review
Tumor cells
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Summary:Ferroptosis, a new type of non-apoptotic cell death modality, is different from other modes of cell death and has been primarily found in tumor cells. Previous studies have reported that ferroptosis can be triggered by specific modulators (e.g., drugs, nutrients, and iron chelators), leading to increased intracellular lipid reactive oxygen species (ROS) accumulation and iron overload. Recent reports have shown that ferroptosis at the cellular and organism levels can prevent an inflammatory storm and cancer development. Emerging evidence suggests potential mechanisms (e.g., system Xc-, glutathione peroxidase 4 (GPX4), lipid peroxidation, glutathione (GSH), and iron chelators) are involved in ferroptosis, which may mediate biological processes such as oxidative stress and iron overload to treat cancer. To date, there are at least three pathways that mediate ferroptosis in cancer cells: system Xc-/GSH/GPX4, FSP1/CoQ10/NAD(P)H, and ATG5/ATG7/NCOA4. Here, we summarize recent advances in the occurrence and development of ferroptosis in the context of cancer, the associations between ferroptosis and various modulators, and the potential mechanisms and therapeutic strategies targeting ferroptosis for the treatment of cancer.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox11081504