Associations of Benzodiazepine With Adverse Prognosis in Heart Failure Patients With Insomnia

Background The prognostic impact of benzodiazepines has been unclear in patients with heart failure (HF). Methods and Results This was a historical observational cohort study. A total of 826 patients who had been hospitalized for HF and were being treated for insomnia with either benzodiazepines or...

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Bibliographic Details
Published in:Journal of the American Heart Association 2020-04, Vol.9 (7), p.e013982
Main Authors: Sato, Yu, Yoshihisa, Akiomi, Hotsuki, Yu, Watanabe, Koichiro, Kimishima, Yusuke, Kiko, Takatoyo, Kanno, Yuki, Yokokawa, Tetsuro, Abe, Satoshi, Misaka, Tomofumi, Sato, Takamasa, Oikawa, Masayoshi, Kobayashi, Atsushi, Yamaki, Takayoshi, Kunii, Hiroyuki, Nakazato, Kazuhiko, Ishida, Takafumi, Takeishi, Yasuchika
Format: Article
Language:English
Subjects:
Aged
Azabicyclo Compounds - adverse effects
benzodiazepine
Benzodiazepines - adverse effects
Eszopiclone - adverse effects
Female
heart failure
Heart Failure - diagnosis
Heart Failure - mortality
Heart Failure - physiopathology
Heart Failure - therapy
Humans
Hypnotics and Sedatives - adverse effects
Male
Middle Aged
Original Research
Patient Readmission
Piperazines - adverse effects
Prognosis
Risk Assessment
Risk Factors
Sleep - drug effects
Sleep Initiation and Maintenance Disorders - diagnosis
Sleep Initiation and Maintenance Disorders - drug therapy
Sleep Initiation and Maintenance Disorders - mortality
Sleep Initiation and Maintenance Disorders - physiopathology
Time Factors
Zolpidem - adverse effects
Z‐drugs
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Summary:Background The prognostic impact of benzodiazepines has been unclear in patients with heart failure (HF). Methods and Results This was a historical observational cohort study. A total of 826 patients who had been hospitalized for HF and were being treated for insomnia with either benzodiazepines or Z-drugs (zolpidem, zopiclone, or eszopiclone), were enrolled and divided on the basis of their hypnotics: benzodiazepine group (n=488 [59.1%]) and Z group (n=338 [40.9%]). We compared the patient characteristics and postdischarge prognosis between the groups. The primary end points were rehospitalization for HF and cardiac death. The benzodiazepine group was older (age, 72.0 versus 69.0 years; =0.010), had a higher prevalence of depression (17.4% versus 8.9%;
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.119.013982