Appearance of Focal Nodular Hyperplasia after Chemotherapy in Two Patients during Follow-Up of Colon Carcinoma

Surgical liver resection is a treatment option in patients with resectable colorectal liver metastases. We present two cases of focal nodular hyperplasia (FNH) development after treatment with oxaliplatin during follow-up of colon carcinoma. The first case was a 40-year-old male patient who develope...

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Published in:Case reports in surgery 2021, Vol.2021, p.6676109-4
Main Authors: de Wert, L. A., Huisman, S. A., Imani, F., de Gooyer, D. J., van Riel, J. M. G. H., Gobardhan, P. D., Rijken, A. M.
Format: Article
Language:English
Subjects:
Abdomen
Ablation
Ablation (Surgery)
Biopsy
Cancer
Carcinoma
Care and treatment
Case Report
Case reports
Chemotherapy
Colon
Colon cancer
Colorectal cancer
Colorectal surgery
Gadoxetate
Hospitals
Hyperplasia
Laparoscopy
Lesions
Liver
Liver diseases
Magnetic resonance imaging
Medical imaging
Metastases
Metastasis
Oxaliplatin
Parenchyma
Patients
Segments
Ultrasonic imaging
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container_title Case reports in surgery
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creator de Wert, L. A.
Huisman, S. A.
Imani, F.
de Gooyer, D. J.
van Riel, J. M. G. H.
Gobardhan, P. D.
Rijken, A. M.
description Surgical liver resection is a treatment option in patients with resectable colorectal liver metastases. We present two cases of focal nodular hyperplasia (FNH) development after treatment with oxaliplatin during follow-up of colon carcinoma. The first case was a 40-year-old male patient who developed multiple liver lesions suspect for metastatic disease four years after he had undergone laparoscopic right-sided hemicolectomy and adjuvant chemotherapy (capecitabine and oxaliplatin). He underwent a metastasectomy of segments three and four and microwave ablation (MWA) of the lesion in segment one. Pathological analysis demonstrated FNH. The second patient was a 21-year-old woman who presented with multiple liver lesions during follow-up for colon carcinoma. She underwent a laparoscopic right-sided hemicolectomy and was adjuvantly treated with capecitabine and oxaliplatin three years ago. Magnetic resonance imaging (MRI) was performed, and the lesions showed no signs of metastatic disease but were classified as FNH. Therefore, the decision was made to follow up the patient. In conclusion, the development of benign liver lesions could occur during follow-up of colon carcinoma and might be caused by oxaliplatin-induced changes to the liver parenchyma. Hence, it is important to distinguish these from metastatic liver disease.
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A. ; Huisman, S. A. ; Imani, F. ; de Gooyer, D. J. ; van Riel, J. M. G. H. ; Gobardhan, P. D. ; Rijken, A. M.</creator><contributor>Ganau, Mario ; Mario Ganau</contributor><creatorcontrib>de Wert, L. A. ; Huisman, S. A. ; Imani, F. ; de Gooyer, D. J. ; van Riel, J. M. G. H. ; Gobardhan, P. D. ; Rijken, A. M. ; Ganau, Mario ; Mario Ganau</creatorcontrib><description>Surgical liver resection is a treatment option in patients with resectable colorectal liver metastases. We present two cases of focal nodular hyperplasia (FNH) development after treatment with oxaliplatin during follow-up of colon carcinoma. The first case was a 40-year-old male patient who developed multiple liver lesions suspect for metastatic disease four years after he had undergone laparoscopic right-sided hemicolectomy and adjuvant chemotherapy (capecitabine and oxaliplatin). He underwent a metastasectomy of segments three and four and microwave ablation (MWA) of the lesion in segment one. Pathological analysis demonstrated FNH. The second patient was a 21-year-old woman who presented with multiple liver lesions during follow-up for colon carcinoma. She underwent a laparoscopic right-sided hemicolectomy and was adjuvantly treated with capecitabine and oxaliplatin three years ago. Magnetic resonance imaging (MRI) was performed, and the lesions showed no signs of metastatic disease but were classified as FNH. Therefore, the decision was made to follow up the patient. In conclusion, the development of benign liver lesions could occur during follow-up of colon carcinoma and might be caused by oxaliplatin-induced changes to the liver parenchyma. 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A. de Wert et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 L. 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A.</au><au>Huisman, S. A.</au><au>Imani, F.</au><au>de Gooyer, D. J.</au><au>van Riel, J. M. G. H.</au><au>Gobardhan, P. D.</au><au>Rijken, A. M.</au><au>Ganau, Mario</au><au>Mario Ganau</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Appearance of Focal Nodular Hyperplasia after Chemotherapy in Two Patients during Follow-Up of Colon Carcinoma</atitle><jtitle>Case reports in surgery</jtitle><addtitle>Case Rep Surg</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>6676109</spage><epage>4</epage><pages>6676109-4</pages><issn>2090-6900</issn><eissn>2090-6919</eissn><abstract>Surgical liver resection is a treatment option in patients with resectable colorectal liver metastases. We present two cases of focal nodular hyperplasia (FNH) development after treatment with oxaliplatin during follow-up of colon carcinoma. 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subjects Abdomen
Ablation
Ablation (Surgery)
Biopsy
Cancer
Carcinoma
Care and treatment
Case Report
Case reports
Chemotherapy
Colon
Colon cancer
Colorectal cancer
Colorectal surgery
Gadoxetate
Hospitals
Hyperplasia
Laparoscopy
Lesions
Liver
Liver diseases
Magnetic resonance imaging
Medical imaging
Metastases
Metastasis
Oxaliplatin
Parenchyma
Patients
Segments
Ultrasonic imaging
title Appearance of Focal Nodular Hyperplasia after Chemotherapy in Two Patients during Follow-Up of Colon Carcinoma
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