Two New Components from an Association of Marine Sponges Poecillastra sp. and Jaspis sp. and Their Inhibitory Effects on Biomarkers for Benign Prostatic Hyperplasia

Benign prostatic hyperplasia (BPH), characterized by the enlargement of the prostate gland and subsequent lower urinary tract symptoms, poses a significant health concern for aging men with increasing prevalence. Extensive efforts encompassing in vitro and in vivo models are underway to identify nov...

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Published in:Marine drugs 2023-09, Vol.21 (9), p.491
Main Authors: Hwang, Buyng Su, Lee, Sangbum, Jeong, Eun Ju, Rho, Jung-Rae
Format: Article
Language:English
Subjects:
(2S, 3S)-capreomycidine
5-alpha reductase type 2
Alzheimer's disease
Amino acids
Antigens
Biomarkers
Carbon
Cell proliferation
Cells
ECD comparison
Genital diseases
Hyperplasia
Jaspis
JBCA
Marine invertebrates
marine sponge
Men
Poecillastra
Proliferation
Prostate
Prostate cancer
Reductases
Sponges
Symptoms
Testosterone
Testosterone propionate
tramiprosate
Urinary tract
Urogenital system
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Summary:Benign prostatic hyperplasia (BPH), characterized by the enlargement of the prostate gland and subsequent lower urinary tract symptoms, poses a significant health concern for aging men with increasing prevalence. Extensive efforts encompassing in vitro and in vivo models are underway to identify novel and effective agents for the management and treatment of BPH. Research endeavors are primarily channeled toward assessing the potential of compounds to inhibit cell proliferation, curb inflammation, and display anti-androgenic activity. Notably, through screening aimed at inhibiting 5-alpha reductase type 2 (5αR2) in human prostatic cells, two acyl compounds (1 and 2) were isolated from a bioactive fraction sourced from an association of marine sponges Poecillastra sp. and Jaspis sp. The complete structure of 1 was determined as (Z)-dec-3-enony (2S, 3S)-capreomycidine, ascertained by JBCA and ECD comparison. While the absolute configurations of 2 remained unassigned, it was identified as a linkage of a 2, 7S*-dihydoxy-9R*-methyloctadecanoyl group with the 2-amino position of a tramiprosate moiety referred to as homotaurine. Evaluation of both compounds encompassed the assessment of their inhibitory effects on key biomarkers (5αR2, AR, PSA, and PCNA) associated with BPH in testosterone propionate (TP)-activated LNCap and RWPE-1 cells.
ISSN:1660-3397
1660-3397
DOI:10.3390/md21090491