Interferon Beta-1b Level in Parkinson’s Disease: Before and After SARS-CoV-2 Vaccination

Background: Parkinson’s disease (PD) is a neurodegenerative disease. Immune response varies after vaccination in different patients. We aimed to evaluate interferon beta-1b (IFNβ-1b) level in patients with PD in response to inactivated SARS-CoV-2 (CoronaVac) vaccination.Methods: Eight patients with...

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Bibliographic Details
Published in:International clinical neuroscience journal 2022-01, Vol.9 (1), p.e23-e23
Main Authors: Yaprak Donmez Cakil, Ozunal, Zeynep Gunes, Karsidag, Sibel, Åžahin, Sevki
Format: Article
Language:English
Subjects:
covid-19
cytokine
immune response
inflammation
interferon beta-1b
parkinson’s disease
vaccination
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Summary:Background: Parkinson’s disease (PD) is a neurodegenerative disease. Immune response varies after vaccination in different patients. We aimed to evaluate interferon beta-1b (IFNβ-1b) level in patients with PD in response to inactivated SARS-CoV-2 (CoronaVac) vaccination.Methods: Eight patients with the diagnosis of idiopathic PD and followed in the outpatient clinic (stages 1-2) were enrolled. Total blood count was performed before vaccination. IFNβ-1b levels were measured by ELISA and motor examination was performed before and two hours after vaccination.Results: IFNβ-1b levels increased in three patients, whereas no change was detected in one patient and the levels decreased in four patients. Divergent responses were found related to the time of diagnosis.Conclusion:The time of PD diagnosis, as well as the age of the patients, may be responsible for the variability of the post-vaccine immune response.
ISSN:2383-1871
2383-2096
DOI:10.34172/icnj.2022.23