Development of a spirometry T-score in the general population

Spirometry values may be expressed as T-scores in standard deviation units relative to a reference in a young, normal population as an analogy to the T-score for bone mineral density. This study was performed to develop the spirometry T-score. T-scores were calculated from lambda-mu-sigma-derived Z-...

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Bibliographic Details
Published in:International journal of chronic obstructive pulmonary disease 2016-01, Vol.11 (1), p.369-379
Main Authors: Lee, Sei Won, Kim, Hyun Kuk, Baek, Seunghee, Jung, Ji-Ye, Kim, Young Sam, Lee, Jae Seung, Lee, Sang-Do, Mannino, David M, Oh, Yeon-Mok
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Bone density
Cause of Death
Chronic obstructive lung disease
Chronic obstructive pulmonary disease
COPD (chronic obstructive pulmonary disease)
Delivery of Health Care - statistics & numerical data
Delivery of Health Care - utilization
Female
Health insurance
Health services utilization
Humans
Insurance claims
Male
Medical prognosis
Middle Aged
Mortality
Nutrition
Original Research
Outcome and Process Assessment (Health Care)
Population
Predictive Value of Tests
Propensity Score
Proportional Hazards Models
Pulmonary Disease, Chronic Obstructive - diagnosis
Pulmonary Disease, Chronic Obstructive - mortality
Reference Values
Republic of Korea - epidemiology
Review boards
Software
Spirometry
Spirometry - methods
Spirometry - standards
Spirometry - statistics & numerical data
Surveys and Questionnaires
T-score
United States - epidemiology
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Summary:Spirometry values may be expressed as T-scores in standard deviation units relative to a reference in a young, normal population as an analogy to the T-score for bone mineral density. This study was performed to develop the spirometry T-score. T-scores were calculated from lambda-mu-sigma-derived Z-scores using a young, normal age reference. Three outcomes of all-cause death, respiratory death, and COPD death were evaluated in 9,101 US subjects followed for 10 years; an outcome of COPD-related health care utilization (COPD utilization) was evaluated in 1,894 Korean subjects followed for 4 years. The probability of all-cause death appeared to remain nearly zero until -1 of forced expiratory volume in 1 second (FEV1) T-score but increased steeply where FEV1 T-score reached below -2.5. Survival curves for all-cause death, respiratory death, COPD death, and COPD utilization differed significantly among the groups when stratified by FEV1 T-score (P
ISSN:1178-2005
1176-9106
1178-2005
DOI:10.2147/COPD.S96117