Correlative studies on vitamin D and total, free bioavailable testosterone levels in young, healthy men

The relationship between vitamin D levels and testicular hormonal function in men has not been clearly established. Therefore, we aimed to investigate the relationship between deficiency/insufficiency levels of 25(OH)D and luteinizing hormone (LH), follicle-stimulating hormone (FSH), total (TT), fre...

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Bibliographic Details
Published in:Scientific reports 2021-10, Vol.11 (1), p.20198-20198, Article 20198
Main Authors: Książek, Anna, Mędraś, Marek, Zagrodna, Aleksandra, Słowińska-Lisowska, Małgorzata, Lwow, Felicja
Format: Article
Language:English
Subjects:
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692/163
Adult
Bioavailability
Chemiluminescence
Cross-Sectional Studies
Enzyme-linked immunosorbent assay
Follicle Stimulating Hormone - blood
Follicle-stimulating hormone
Globulins
Healthy Volunteers
Humanities and Social Sciences
Humans
Luteinizing hormone
Luteinizing Hormone - blood
Male
multidisciplinary
Poland
Population genetics
Science
Science (multidisciplinary)
Serum levels
Sex Hormone-Binding Globulin - metabolism
Sex hormones
Testosterone
Testosterone - blood
Vitamin D
Vitamin D - blood
Young Adult
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Summary:The relationship between vitamin D levels and testicular hormonal function in men has not been clearly established. Therefore, we aimed to investigate the relationship between deficiency/insufficiency levels of 25(OH)D and luteinizing hormone (LH), follicle-stimulating hormone (FSH), total (TT), free (FT), and bioavailable testosterone (BT), and sex hormone binding globulin (SHBG) in young, healthy men. We enrolled 176 healthy, active young men aged 18–35 years from a genetically homogenous population of Lower Silesia, Poland. Serum levels of 25(OH)D, LH, FSH, and TT were measured by electrochemiluminescence (ECLIA). FT levels were measured by enzyme-linked immunosorbent assay (ELISA). BT levels were calculated from TT, SHBG, and albumin. SHBG was measured by chemiluminescent immunoassay CLIA. We did not find any significant differences between the mean hormonal values (LH, FSH, TT, FT, BT, and SHBG) and the status of 25(OH)D level (deficient and insufficient). Based on our results, we concluded that there is no relationship between deficient and insufficient 25(OH)D concentration and androgen levels in young, healthy men.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-99571-8