Exploring the link between sedentary behavior and cognitive decline: a comprehensive study combining Mendelian randomization and animal model experiments

The causal link between detrimental behaviors and cognitive performance remains unclear. This research seeks to investigate the causal impact of adjustable lifestyle factors on cognitive deterioration, including frequency of alcohol intake, onset of smoking, and sedentary activities like prolonged t...

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Bibliographic Details
Published in:Frontiers in psychology 2024-10, Vol.15, p.1407846
Main Authors: Bai, Yupeng, Liu, Mengke, Fang, Yan, Zhan, Ruonan
Format: Article
Language:English
Subjects:
cognitive function
multivariable Mendelian randomization
physical exercise
Psychology
synaptic plasticity
time spent watching television
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Summary:The causal link between detrimental behaviors and cognitive performance remains unclear. This research seeks to investigate the causal impact of adjustable lifestyle factors on cognitive deterioration, including frequency of alcohol intake, onset of smoking, and sedentary activities like prolonged television viewing. This research combines large-scale genetic data obtained from univariable and multivariable Mendelian randomization analyses with experimental findings obtained from animal models. Our findings reveal that the odds ratio (OR) for cognitive function deterioration was 0.445 (inverse variance weighted [IVW] 95% CI: 0.370 to 0.536,  
ISSN:1664-1078
1664-1078
DOI:10.3389/fpsyg.2024.1407846